The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Piezo1 regulates mechanotransductive release of ATP from human RBCs
Open accessAbstract
Significance: Mechanotransductive release of ATP from RBCs participates in the regulation of microvascular tone and plays essential roles in vascular physiopathology. The mechanism responsible for the release of ATP, however, is poorly understood. We show for the first time, to our knowledge, that Piezo1, the recently identified mechanically activated cation channel, regulates the mechanotransductive release of ATP from RBCs. In particular, we uncover the link between Piezo1, calcium influx, and ATP release and propose a previously unidentified mechanotransductive pathway that modulates the release of ATP from RBCs. The outcome of this study will allow the development of much needed approaches to regulate the release of ATP from RBCs and thus, impact significantly the fields of red cell research, cellular mechanosensing, and Piezo1 channels.
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“Shear stress, hypoxia, or pharmacological stimuli, such as β-adrenergic receptor stimulation, have been shown to activate signaling cascades leading to release of ATP through cystic fibrosis transmembrane conductance regulator or pannexin 1 channels (36, 53).”
From Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia (2017) · cites this paper as [36]
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Cites
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
Coste, B., Mathur, J., Schmidt, M., Earley, T. J., Ranade, S., Petrus, M. J., Dubin, A. E., & Patapoutian, A. (2010) · Science · doi:10.1126/science.1193270 · Cited by 3,316
Piezo1 integration of vascular architecture with physiological force
Li, J., Hou, B., Tumova, S., Muraki, K., Bruns, A. F., Ludlow, M. J., Sedó, A., Hyman, A. J., McKeown, L., Young, R. S., et al. (2014) · Nature · doi:10.1038/nature13701 · Cited by 1,250
Piezo proteins are pore-forming subunits of mechanically activated channels
Coste, B., Xiao, B., Santos, J. S., Syeda, R., Grandl, J. M., Spencer, K. S. R., Kim, S. E., Schmidt, M., Mathur, J., Dubin, A. E., et al. (2012) · Nature · doi:10.1038/nature10812 · Cited by 1,205
Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
Chekeni, F. B., Elliott, M. R., Sandilos, J. K., Walk, S. F., Kinchen, J. M., Lazarowski, E. R., Armstrong, A. J., Penuela, S., Laird, D. W., Salvesen, G. S., et al. (2010) · Nature · doi:10.1038/nature09413 · Cited by 1,120
Piezo1, a mechanically activated ion channel, is required for vascular development in mice
Ranade, S. S., Qiu, Z., Woo, S., Hur, S. S., Murthy, S. E., Cahalan, S. M., Xu, J., Mathur, J., Bandell, M., Coste, B., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409233111 · Cited by 931
Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells
Pathak, M. M., Nourse, J. L., Tran, T., Hwe, J., Arulmoli, J., Le, D. T. T., Bernardis, E., Flanagan, L. A., & Tombola, F. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409802111 · Cited by 657
Calcium pump of the plasma membrane
Carafoli, E. (1991) · Physiological Reviews · doi:10.1152/physrev.1991.71.1.129 · Cited by 654
Piezo1 links mechanical forces to red blood cell volume
Cahalan, S. M., Lukacs, V., Ranade, S. S., Chien, S., Bandell, M., & Patapoutian, A. (2015) · eLife · doi:10.7554/elife.07370 · Cited by 630
The Mechanosensitive Ion Channel Piezo1 Is Inhibited by the Peptide GsMTx4
Bae, C., Sachs, F., & Gottlieb, P. A. (2011) · Biochemistry · doi:10.1021/bi200770q · Cited by 566
The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes
Silverman, W. R., Vaccari, J. P. D. R., Locovei, S., Qiu, F., Carlsson, S. K., Scemes, E., Keane, R. W., & Dahl, G. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.004804 · Cited by 549
Cited by
Sorted by citations
Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets
Di, X., Gao, X., Peng, L., Ai, J., Jin, X., Qi, S., Li, H., Wang, K., & Luo, D. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01501-9 · Cited by 715
Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release
Wang, S., Chennupati, R., Kaur, H., Iring, A., Wettschureck, N., & Offermanns, S. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87343 · Cited by 616
Touch, Tension, and Transduction – The Function and Regulation of Piezo Ion Channels
Wu, J. H., Lewis, A. H., & Grandl, J. M. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.09.004 · Cited by 586
Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia
Kuhn, V., Diederich, L., Keller, T. C. S., Kramer, C. M., Lückstädt, W., Panknin, C., Suvorava, T., Isakson, B. E., Kelm, M., & Cortese-Krott, M. M. (2017) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6954 · Cited by 469
Purinergic Signaling in the Cardiovascular System
Burnstock, G. (2017) · Circulation Research · doi:10.1161/circresaha.116.309726 · Cited by 420
Metadata
- Authors
- Cinar, E., Zhou, S., DeCourcey, J., Wang, Y., Waugh, R. E., & Wan, J.
- Affiliations
- Microsystems Engineering, Rochester Institute of Technology, Rochester, NY 14623;
- Rochester Institute of Technology (US)
- University of Rochester (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-09-08
- Volume
- 112
- Issue
- 38
- Pages
- 11783-11788
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4586865
- OpenAlex
- W1684606992
- Cited by
- 206
- References
- 59
- Citations by year
- 2026: 17 · 2025: 17 · 2024: 17 · 2023: 17 · 2022: 30 · 2021: 22 · 2020: 16 · 2019: 22 · 2018: 16 · 2017: 22 · 2016: 10
- FWCI
- 11.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Erythrocyte Function and Pathophysiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- Piezo1, mechanotransduction, ATP release, human erythrocytes, extracellular calcium, hereditary xerocytosis, red cell disorders
- MeSH terms
- Adenosine Triphosphate, Calcium, Calibration, Erythrocyte Membrane, Erythrocytes, Extracellular Space, Humans, Ion Channels, Models, Biological, Shear Strength, Mechanotransduction, Cellular, Microfluidics
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