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Cited by 123

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation

Goth, Christoffer K., Halim, Adnan, Khetarpal, Sumeet A., Rader, Daniel J., Clausen, Henrik, Schjoldager, Katrine T.-B. G.·2015·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1511175112
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Abstract

Significance: Ectodomain shedding is a central event in a range of biological processes and pathways, however the underlying mechanisms are still not fully understood. Here we present evidence that site-specific O-glycosylation regulated by individual GalNAc-Transferase isoforms, serve to coregulate ectodomain shedding, predominantly through blocking of cleavage. Our general finding is exemplified by the specific role of a single GalNAc-T isoform (GalNAc-T2) in coregulating TNF-alpha release in vitro, ex vivo in isogenic cell models, and in vivo in mouse Galnt2 knockouts. Adding the large family of GalNAc-T isoforms to regulation of ectodomain shedding substantially increase the ability to fine-tune this important process on a substrate level.

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  • A recent study showed that ADAM17-mediated cleavage was negatively affected by O-glycosylation in most substrates, especially O-glycosylation sites within four amino acid residues from the cleavage sites.

    “A recent study showed that ADAM17-mediated cleavage was negatively affected by O-glycosylation in most of the substrates, especially O-glycosylation sites within four amino acid residues from the cleavage sites (31).”

    From ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium (2021) · cites this paper as [31]

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Citations

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Research works printed but not linked: 42

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Metadata

Authors
Goth, C. K., Halim, A., Khetarpal, S. A., Rader, D. J., Clausen, H., & Schjoldager, K. T.-B. G.
Affiliations
  • Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark;
  • Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2015-11-09
Volume
112
Issue
47
Pages
14623-14628
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.1511175112
Cited by
123
References
4
Language
en
Licence
www.pnas.org/site/misc/userlicense.xhtml (vor, 182 d)
Funders
Danish National Research Foundation (DNRF107)

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