The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Zinc-dependent mechanical properties of Staphylococcus aureus biofilm-forming surface protein SasG
Open accessAbstract
Significance: Hospital-acquired infections often involve surface-associated microbial communities called biofilms that show increased resistance to antibiotics. A molecular understanding of the fundamental interactions driving adhesion and biofilm formation by microbial pathogens is a key step toward the development of novel antimicrobial therapies. Here we demonstrate that the SasG surface protein from Staphylococcus aureus displays remarkable zinc-dependent mechanical properties that are critical for its adhesive function during biofilm formation. We find that zinc activates SasG-mediated adhesion through a mechanism whereby adsorption of zinc ions to the bacterial cell surface increases cell wall cohesion and favors zinc-dependent homophilic bonds between SasG proteins protruding from opposing cell surfaces. The zinc-dependent adhesive function of SasG represents a promising target for the design of antibacterial compounds.
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“S. aureus surface protein G (SasG) causes intercellular adhesion and promotes biofilm formation through zinc-dependent dimerization [59].”
From A Review of Biofilm Formation of Staphylococcus aureus and Its Regulation Mechanism (2022) · cites this paper as [59]
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Cites
Hobley, L., Harkins, C., MacPhee, C. E., & Stanley-Wall, N. R. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv015 · Cited by 581 · cited 2×
“A prototype of biofilm-forming CWA protein is SasG (12–15), which mediates cell–cell adhesion through its “B” multidomain region (5, 7).”
BackgroundConrady, D. G., Brescia, C. C., Horii, K., Weiss, A. A., Hassett, D. J., & Herr, A. B. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807717105 · Cited by 216
Cited by
Atomic force microscopy-based mechanobiology
Krieg, M., Fläschner, G., Alsteens, D., Gaub, B. M., Roos, W. H., Wuite, G. J. L., Gaub, H. E., Gerber, C., Dufrêne, Y. F., & Müller, D. J. (2018) · Nature Reviews Physics · doi:10.1038/s42254-018-0001-7 · Cited by 799
Self-citationStaphylococcal Biofilm Development: Structure, Regulation, and Treatment Strategies
Schilcher, K., & Horswill, A. R. (2020) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00026-19 · Cited by 706
A Review of Biofilm Formation of Staphylococcus aureus and Its Regulation Mechanism
Peng, Q., Tang, X., Dong, W., Sun, N., & Yuan, W. (2022) · Antibiotics · doi:10.3390/antibiotics12010012 · Cited by 440
Staphylococcus epidermidis and its dual lifestyle in skin health and infection
Severn, M. M., & Horswill, A. R. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00780-3 · Cited by 355
Mechanomicrobiology: how bacteria sense and respond to forces
Dufrêne, Y. F., & Persat, A. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0314-2 · Cited by 299
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Metadata
- Authors
- Formosa-Dague, C., Speziale, P., Foster, T. J., Geoghegan, J. A., & Dufrêne, Y. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-12-29
- Volume
- 113
- Issue
- 2
- Pages
- 410-415
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2204278633
- Cited by
- 171
- References
- 2
- FWCI
- 6.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Formosa-Dague, C., Speziale, P., Foster, T. J., Geoghegan, J. A., & Dufrêne, Y. F. (2016). Zinc-dependent mechanical properties of Staphylococcus aureus biofilm-forming surface protein SasG. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1519265113
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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