The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The GSK3-like kinase BIN2 phosphorylates and destabilizes BZR1, a positive regulator of the brassinosteroid signaling pathway in Arabidopsis
Open accessAbstract
Brassinosteroids (BRs) are a class of steroid hormones essential for normal growth and development in plants. BR signaling involves the cell-surface receptor BRI1, the glycogen synthase kinase-3-like kinase BIN2 as a negative regulator, and nuclear proteins BZR1 and BZR2/BES1 as positive regulators. The interactions among these components remain unclear. Here we report that BRs induce dephosphorylation and accumulation of BZR1 protein. Experiments using a proteasome inhibitor, MG132, suggest that phosphorylation of BZR1 increases its degradation by the proteasome machinery. BIN2 directly interacts with BZR1 in yeast two-hybrid assays, phosphorylates BZR1 in vitro , and negatively regulates BZR1 protein accumulation in vivo . These results strongly suggest that BIN2 phosphorylates BZR1 and targets it for degradation and that BR signaling causes BZR1 dephosphorylation and accumulation by inhibiting BIN2 activity.
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Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
BRASSINOSTEROIDS: Essential Regulators of Plant Growth and Development
Clouse, S. D., & Sasse, J. M. (1998) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.49.1.427 · Cited by 1,462
Cited by
Kim, T.-W., Guan, S., Sun, Y., Deng, Z., Tang, W., Shang, J.-X., Sun, Y., Burlingame, A. L., & Wang, Z.-Y. (2009) · Nature Cell Biology · doi:10.1038/ncb1970 · Cited by 693
Self-citationTanabe, S., Ashikari, M., Fujioka, S., Takatsuto, S., Yoshida, S., Yano, M., Yoshimura, A., Kitano, H., Matsuoka, M., Fujisawa, Y., et al. (2005) · The Plant Cell · doi:10.1105/tpc.104.024950 · Cited by 555
GW5 acts in the brassinosteroid signalling pathway to regulate grain width and weight in rice
Liu, J., Chen, J., Zheng, X., Wu, F., Lin, Q., Heng, Y., Tian, P., Cheng, Z., Yu, X., Zhou, K., et al. (2017) · Nature Plants · doi:10.1038/nplants.2017.43 · Cited by 555
Brassinosteroid Signaling Network and Regulation of Photomorphogenesis
Wang, Z.-Y., Bai, M.-Y., Oh, E., & Zhu, J.-Y. (2012) · Annual Review of Genetics · doi:10.1146/annurev-genet-102209-163450 · Cited by 490
Self-citationLi, H., Ye, K., Shi, Y., Cheng, J., Zhang, X., & Yang, S. (2017) · Molecular Plant · doi:10.1016/j.molp.2017.01.004 · Cited by 426
Metadata
- Authors
- He, J.-X., Gendron, J. M., Yang, Y., Li, J., & Wang, Z.-Y.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-07-11
- Volume
- 99
- Issue
- 15
- Pages
- 10185-10190
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2061619931
- Cited by
- 717
- References
- 2
- FWCI
- 28.21
- Type
- journal article
- Language
- en
- Open access
- green
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- He, J.-X., Gendron, J. M., Yang, Y., Li, J., & Wang, Z.-Y. (2002). The GSK3-like kinase BIN2 phosphorylates and destabilizes BZR1, a positive regulator of the brassinosteroid signaling pathway in Arabidopsis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.152342599
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