The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Clusters of circulating tumor cells traverse capillary-sized vessels
Open accessAbstract
Significance: Metastasis is responsible for 90% of cancer-related deaths and is driven by tumor cells circulating in blood. However, it is believed that only individual tumor cells can reach distant organs because multicellular clusters are too large to pass through narrow capillaries. Here, we collected evidence by examining clusters in microscale devices, computational simulations, and animals, which suggest that this assumption is incorrect, and that clusters may transit through capillaries by unfolding into single-file chains. This previously unidentified cell behavior may explain why previous experiments reported that clusters were more efficient at seeding metastases than equal numbers of single tumor cells, and has led to a strategy that, if applied clinically, may reduce the incidence of metastasis in patients.
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Cites
Calcium's Role in Mechanotransduction during Muscle Development
Benavides Damm, T., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,502
An Introduction to Fluid Dynamics
Batchelor, G. K. (2000) · doi:10.1017/cbo9780511800955 · Cited by 12,360
An introduction to fluid dynamics
Curle, N. (1968) · International Journal of Heat and Mass Transfer · doi:10.1016/0017-9310(68)90038-0 · Cited by 6,135
A Perspective on Cancer Cell Metastasis
Chaffer, C. L., & Weinberg, R. A. (2011) · Science · doi:10.1126/science.1203543 · Cited by 4,807
Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
Yu, M., Bardia, A., Wittner, B. S., Stott, S. L., Smas, M. E., Ting, D. T., Isakoff, S. J., Ciciliano, J. C., Wells, M. N., Shah, A. M., et al. (2013) · Science · doi:10.1126/science.1228522 · Cited by 2,476
Self-citationCirculating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis
Aceto, N., Bardia, A., Miyamoto, D. T., Donaldson, M. C., Wittner, B. S., Spencer, J. A., Yu, M., Pely, A., Engstrom, A., Zhu, H., et al. (2014) · Cell · doi:10.1016/j.cell.2014.07.013 · Cited by 2,441
Self-citationIsolation of circulating tumor cells using a microvortex-generating herringbone-chip
Stott, S. L., Hsu, C.-H., Tsukrov, D. I., Yu, M., Miyamoto, D. T., Waltman, B. A., Rothenberg, S. M., Shah, A. M., Smas, M. E., Korir, G. K., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012539107 · Cited by 1,634
Self-citationJaalouk, D. E., & Lammerding, J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2597 · Cited by 1,396
Circulating tumor cells: approaches to isolation and characterization
Yu, M., Stott, S., Toner, M., Maheswaran, S., & Haber, D. A. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201010021 · Cited by 1,089
Self-citationBlood Rheology and Hemodynamics
(2003) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2003-44551 · Cited by 1,006
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Nieto, M. A., Huang, R. Y.-J., Jackson, R. A., & Thiery, J. P. (2016) · Cell · doi:10.1016/j.cell.2016.06.028 · Cited by 4,492
Wei, C., Yang, C., Wang, S., Shi, D., Zhang, C., Lin, X., Liu, Q., Dou, R., & Xiong, B. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0976-4 · Cited by 833
Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
Huang, G., Li, F., Zhao, X., Ma, Y., Li, Y., Lin, M., Jin, G., Lu, T. J., Genin, G. M., & Xu, F. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00094 · Cited by 825
Unravelling tumour heterogeneity by single-cell profiling of circulating tumour cells
Keller, L., & Pantel, K. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0180-2 · Cited by 544
Organ-on-chip models of cancer metastasis for future personalized medicine: From chip to the patient
Caballero, D., Kaushik, S., Correlo, V. M., Oliveira, J. M., Reis, R. L., & Kundu, S. C. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.10.005 · Cited by 221
Metadata
- Authors
- Au, S. H., Storey, B. D., Moore, J. C., Tang, Q., Chen, Y.-L., Javaid, S., Sarioglu, A. F., Sullivan, R., Madden, M. W., O’Keefe, R., Haber, D. A., Maheswaran, S., Langenau, D. M., Stott, S. L., & Toner, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2016-04-18
- Volume
- 113
- Issue
- 18
- Pages
- 4947-4952
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2336248112
- Cited by
- 478
- References
- 47
- FWCI
- 26.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Au, S. H., Storey, B. D., Moore, J. C., Tang, Q., Chen, Y.-L., Javaid, S., Sarioglu, A. F., Sullivan, R., Madden, M. W., O’Keefe, R., Haber, D. A., Maheswaran, S., Langenau, D. M., Stott, S. L., & Toner, M. (2016). Clusters of circulating tumor cells traverse capillary-sized vessels. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1524448113
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