The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Designing allostery-inspired response in mechanical networks
Open accessAbstract
Recent advances in designing metamaterials have demonstrated that global mechanical properties of disordered spring networks can be tuned by selectively modifying only a small subset of bonds. Here, using a computationally efficient approach, we extend this idea to tune more general properties of networks. With nearly complete success, we are able to produce a strain between any two target nodes in a network in response to an applied source strain on any other pair of nodes by removing only ∼1% of the bonds. We are also able to control multiple pairs of target nodes, each with a different individual response, from a single source, and to tune multiple independent source/target responses simultaneously into a network. We have fabricated physical networks in macroscopic 2D and 3D systems that exhibit these responses. This work is inspired by the long-range coupled conformational changes that constitute allosteric function in proteins. The fact that allostery is a common means for regulation in biological molecules suggests that it is a relatively easy property to develop through evolution. In analogy, our results show that long-range coupled mechanical responses are similarly easy to achieve in disordered networks.
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“Optimizing the networks for a geometric task, by selecting network structures where binding a ligand leads to a defined displacement on the other side of the network (“active site”), yields networks displaying a powerful lever at the active site, where the signal is required (Flechsig, 2017; Rocks et al., 2017; Yan et al., 2017a, 2017b).”
From Allostery in Its Many Disguises: From Theory to Applications (2019) · cites this paper as Rocks et al., 2017
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Citations
Cites
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Background
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New frontiers for the materials genome initiative
Pablo, J., Jackson, N. E., Webb, M. A., Chen, L., Moore, J. E., Morgan, D. D., Jacobs, R. M., Pollock, T. M., Schlom, D. G., Toberer, E. S., et al. (2019) · npj Computational Materials · doi:10.1038/s41524-019-0173-4 · Cited by 594
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Allostery in Its Many Disguises: From Theory to Applications
Wodak, S. J., Paci, E., Dokholyan, N. V., Berezovsky, I. N., Horovitz, A., Li, J., Hilser, V. J., Bahar, I., Karanicolas, J., Stock, G., et al. (2019) · Structure · doi:10.1016/j.str.2019.01.003 · Cited by 404
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Network analysis of particles and grains
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Background
Metadata
- Authors
- Rocks, J. W., Pashine, N., Bischofberger, I., Goodrich, C. P., Liu, A. J., & Nagel, S. R.
- Affiliations
- University of Pennsylvania (US)
- University of Chicago (US)
- Massachusetts Institute of Technology (US)
- Harvard University (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2017-02-21
- Volume
- 114
- Issue
- 10
- Pages
- 2520-2525
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5347623
- OpenAlex
- W2485975781
- Cited by
- 204
- References
- 33
- Citations by year
- 2026: 17 · 2025: 34 · 2024: 18 · 2023: 22 · 2022: 12 · 2021: 27 · 2020: 22 · 2019: 29 · 2018: 14 · 2017: 8
- FWCI
- 15.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- arXiv (Cornell University) (submittedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- arXiv (Cornell University)
- Funders
- U.S. Department of Energy (DE-FG02-05ER46199, DE-FG02-03ER46088)
- National Science Foundation Graduate Research Fellowship Program (DGE-1321851)
- Simons Foundation (305547, 327939)
- DOC | National Institute of Standards and Technology (60NANB15D055)
- Topics
- Physical Sciences › Engineering › Mechanical Engineering › Advanced Materials and Mechanics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Physical Sciences › Physics and Astronomy › Acoustics and Ultrasonics › Acoustic Wave Phenomena Research
- Keywords
- allosteric regulation, mechanical metamaterials, spring networks, strain amplification, disordered networks, protein conformational change, network design
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