Modular tissue engineering for the vascularization of subcutaneously transplanted pancreatic islets
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Significance: In this study we show that pancreatic islets embedded in modules coated with endothelial cells and injected under the skin return streptozotocin-induced diabetic SCID/beige mice to normoglycemia. The transplanted islets became revascularized and directly integrated with host’s vasculature, a feature not seen previously in the subcutaneous space. These implants were also retrievable, an important clinical consideration. The success here means that islet transplantation can move away from inhospitable sites such as the peritoneal cavity or the liver.
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Islets embedded within sub-millimeter collagen cylinders coated with endothelial cells or combined with microvascular fragments became rapidly vascularized and connected to the host vasculature when transplanted into rodents.
“Alternatively, islets embedded within sub-millimeter collagen cylinders coated with endothelial cells154 or islets combined with microvascular fragments155 were demonstrated to become rapidly vascularized and connected to the host vasculature when transplanted into rodents.”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [154]
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References 54 · Cited by 132
Research works printed but not linked: 2
- Iuamoto LR, et al. (2017) Human islet xenotransplantation in rodents: A literature review of experimental model trends. Clinics (Sao Paulo) 72:238-243.
- West M, Sefton MV (2016) Enhanced vascularization of modular engineered tissues using activated macrophages. PhD thesis (University of Toronto, Toronto). pp 1-70.
- Authors
- Vlahos, A. E., Cober, N., & Sefton, M. V.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Sefton, Michael V.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2017-08-16
- Volume
- 114
- Issue
- 35
- Pages
- 9337-9342
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5584405
- OpenAlex
- W2746879174
- Cited by
- 132
- References
- 54
- Citations by year
- 2026: 3 · 2025: 15 · 2024: 16 · 2023: 13 · 2022: 11 · 2021: 16 · 2020: 21 · 2019: 21 · 2018: 16
- FWCI
- 16.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Gouvernement du Canada | Canadian Institutes of Health Research (142406)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- islet transplantation, subcutaneous transplantation, vascularization, type 1 diabetes, islet revascularization, M2 macrophages, streptozotocin-induced diabetes, SCID/beige mice, Edmonton protocol
- MeSH terms
- Animals, Blood Glucose, Diabetes Mellitus, Experimental, Humans, Islets of Langerhans, Islets of Langerhans Transplantation, Mice, SCID, Tissue Engineering, Mice, Rats, Human Umbilical Vein Endothelial Cells
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