The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Chromatin assembly factor 1 is essential and couples chromatin assembly to DNA replication in vivo
Open accessAbstract
De novo chromatin assembly maintains histone density on the daughter strands in the wake of the replication fork. The heterotrimer chromatin assembly factor 1 (CAF-1) couples DNA replication to histone deposition in vitro , but is not essential for yeast cell proliferation. Depletion of CAF-1 in human cell lines demonstrated that CAF-1 was required for efficient progression through S-phase. Cells lacking CAF-1 accumulated in early and mid S-phase and replicated DNA slowly. The checkpoint kinase Chk1, but not Chk2, was phosphorylated in response to CAF-1 depletion, consistent with a DNA replication defect. CAF-1-depleted cell extracts completely lacked DNA replication-coupled chromatin assembly activity, suggesting that CAF-1 is required for efficient S-phase progression in human cells. These results indicate that, in contrast to yeast, human CAF-1 is necessary for coupling chromatin assembly with DNA replication.
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Cites
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
Waga, S., Hannon, G. J., Beach, D., & Stillman, B. (1994) · Nature · doi:10.1038/369574a0 · Cited by 1,655
Self-citationATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1
Zhao, H., & Piwnica-Worms, H. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.13.4129-4139.2001 · Cited by 1,091
Heterochromatin Dynamics in Mouse Cells
Murzina, N., Verreault, A., Laue, E., & Stillman, B. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80204-x · Cited by 300
Self-citationWAF1 retards S-phase progression primarily by inhibition of cyclin-dependent kinases
Ogryzko, V. V., Wong, P., & Howard, B. H. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.8.4877 · Cited by 193
Cited by
Lämke, J., & Bäurle, I. (2017) · Genome Biology · doi:10.1186/s13059-017-1263-6 · Cited by 893
CBP/p300-mediated acetylation of histone H3 on lysine 56
Das, C., Lucia, M. S., Hansen, K. C., & Tyler, J. K. (2009) · Nature · doi:10.1038/nature07861 · Cited by 697
Kobor, M. S., Venkatasubrahmanyam, S., Meneghini, M. D., Gin, J. W., Jennings, J. L., Link, A. J., Madhani, H. D., & Rine, J. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020131 · Cited by 613
Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres
O'Sullivan, R. J., Kubicek, S., Schreiber, S. L., & Karlseder, J. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1897 · Cited by 416
The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence
Mallette, F. A., Gaumont-Leclerc, M.-F., & Ferbeyre, G. (2007) · Genes & Development · doi:10.1101/gad.1487307 · Cited by 406
Metadata
- Authors
- Hoek, M., & Stillman, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-09-30
- Volume
- 100
- Issue
- 21
- Pages
- 12183-12188
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2044941418
- Cited by
- 248
- References
- 4
- FWCI
- 5.04
- Type
- journal article
- Language
- en
- Open access
- green
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