Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology
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Significance: Although gamma delta (γδ) T cells compose an evolutionarily conserved third lineage of diversified lymphocytes, alongside αβ T cells and B cells, they can seem overtly different across species and tissues. Thus, human blood γδ cells show butyrophilin (BTN)3A1-dependent responses to metabolites (“phosphoantigens”) not seen by rodent γδ cells, whereas some rodent, γδ-rich compartments, notably in the skin, lack obvious human counterparts. Recently, however, mouse and human intraepithelial gut γδ cells were found to be regulated by pairings of BTN-like genes. This study now shows that BTN3A1 also functions as a pairing, with its subcellular trafficking and optimal activity both regulated by BTN3A2. Hence, seemingly diverse γδ cell biologies across species and tissues are underpinned by conserved mechanisms.
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Butyrophilins (BTN3A1 and BTN3A2/3) are important for Vγ9Vδ2+ T cell recognition.
“Third, consistent with related immunobiology, butyrophilins (BTN3A1 and BTN3A2/3) are important for Vγ9Vδ2+ T cell recognition (22).”
From Comparing Mouse and Human Tissue-Resident γδ T Cells (2022) · cites this paper as [22]
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Comparing Mouse and Human Tissue-Resident γδ T Cells
Qu, G., Wang, S., Zhou, Z., Jiang, D., Liao, A., & Luo, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.891687 · Cited by 87 · see citing works
- Authors
- Vantourout, P., Laing, A., Woodward, M. J., Zlatareva, I., Apolonia, L., Jones, A. W., Snijders, A. P., Malim, M. H., & Hayday, A. C.
- Affiliations
- King's College London (GB)
- The Francis Crick Institute (GB)
- Corresponding author
- Hayday, Adrian C.
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2018-01-16
- Volume
- 115
- Issue
- 5
- Pages
- 1039-1044
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5798315
- OpenAlex
- W2784098749
- Cited by
- 173
- References
- 1
- Citations by year
- 2026: 14 · 2025: 17 · 2024: 18 · 2023: 23 · 2022: 15 · 2021: 21 · 2020: 36 · 2019: 15 · 2018: 14
- FWCI
- 9.35
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, cc-by-nc-nd)
- Figshare (submittedVersion, cc-by-nc-nd)
- Funders
- Wellcome (106292/Z/14/Z, 100156/Z/12/Z, 106223/Z/14/Z)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- butyrophilin, BTN3A1, BTN3A2, γδ T cells, phosphoantigens, intracellular trafficking
- MeSH terms
- Butyrophilins, Animals, Endoplasmic Reticulum, Humans, Lymphocyte Activation, Antigens, CD, T-Lymphocyte Subsets, Receptors, Antigen, T-Cell, gamma-delta, Amino Acid Motifs, Mice, Protein Multimerization, HEK293 Cells
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