The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD
Open accessAbstract
Cytokines often deliver simultaneous, yet distinct, cell growth and cell survival signals. The 70-kDa ribosomal protein S6 kinase (p70S6K) is known to regulate cell growth by inducing protein synthesis components. We purified membrane-based p70S6K as a kinase responsible for site-specific phosphorylation of BAD, which inactivates this proapoptotic molecule. Rapamycin inhibited mitochondrial-based p70S6K, which prevented phosphorylation of Ser-136 on BAD and blocked cell survival induced by insulin-like growth factor 1 (IGF-1). Moreover, IGF-1-induced phosphorylation of BAD Ser-136 was abolished in p70S6K-deficient cells. Thus, p70S6K is itself a dual pathway kinase, signaling cell survival as well as growth through differential substrates which include mitochondrial BAD and the ribosomal subunit S6, respectively.
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1 retracted
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The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins
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Metadata
- Authors
- Harada, H., Andersen, J. S., Mann, M., Terada, N., & Korsmeyer, S. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-08-07
- Volume
- 98
- Issue
- 17
- Pages
- 9666-9670
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2050988292
- Cited by
- 549
- References
- 51
- FWCI
- 10.53
- Type
- journal article
- Language
- en
- Open access
- green
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- Harada, H., Andersen, J. S., Mann, M., Terada, N., & Korsmeyer, S. J. (2001). p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.171301998
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