The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors
Open accessAbstract
Significance: Pancreatic ductal adenocarcinoma is one of the most malignant human tumors for which there are no efficacious therapeutic strategies. This tumor type is characterized by an abundant desmoplastic stroma that promotes tumor progression. Yet recent studies have shown that physical or genetic elimination of the stroma leads to more aggressive tumor development. Here, we decided to reprogram the stromal tissue by identifying and subsequently targeting genes responsible for their protumorigenic properties. Comparative transcriptome analysis revealed several genes overexpressed in cancer-associated fibroblasts compared with those present in normal pancreata. We provide genetic evidence that one of these genes, Saa3 , plays a key role on the protumorigenic properties of the stroma, opening the door to the design of future therapeutic strategies.
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Cites
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Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
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Cited by
Elyada, E., Bolisetty, M., Laise, P., Flynn, W. F., Courtois, E. T., Burkhart, R. A., Teinor, J. A., Belleau, P., Biffi, G., Lucito, M. S., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0094 · Cited by 2,241
Diversity and biology of cancer-associated fibroblasts
Biffi, G., & Tuveson, D. A. (2021) · Physiological Reviews · doi:10.1152/physrev.00048.2019 · Cited by 1,265
Pancreatic cancer stroma: an update on therapeutic targeting strategies
Hosein, A. N., Brekken, R. A., & Maitra, A. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0300-1 · Cited by 950
Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer
Wu, F., Yang, J., Liu, J., Wang, Y., Mu, J., Zeng, Q., Deng, S., & Zhou, H. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00641-0 · Cited by 773
Sack, G. H. (2018) · Molecular Medicine · doi:10.1186/s10020-018-0047-0 · Cited by 499
Metadata
- Authors
- Djurec, M., Graña, O., Lee, A., Troulé, K., Espinet, E., Cabras, L., Navas, C., Blasco, M. T., Martín-Díaz, L., Burdiel, M., Li, J., Liu, Z., Vallespinós, M., Sanchez-Bueno, F., Sprick, M. R., Trumpp, A., Sainz, B., Al-Shahrour, F., Rabadan, R., Guerra, C., & Barbacid, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2018-01-19
- Volume
- 115
- Issue
- 6
- Pages
- E1147-E1156
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2783528540
- Cited by
- 178
- References
- 14
- FWCI
- 6.91
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Djurec, M., Graña, O., Lee, A., Troulé, K., Espinet, E., Cabras, L., Navas, C., Blasco, M. T., Martín-Díaz, L., Burdiel, M., Li, J., Liu, Z., Vallespinós, M., Sanchez-Bueno, F., Sprick, M. R., Trumpp, A., Sainz, B., Al-Shahrour, F., Rabadan, R., . . . Barbacid, M. (2018). Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1717802115
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
