The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2
Open accessAbstract
Significance: Curcumin is an ancient drug derived from turmeric and has been found to exhibit potent anticancer properties albeit through controversial mechanisms of action. Using a biochemical model, mouse cancer model, and cellular models, we show that curcumin is a highly potent and selective inhibitor of dual-specificity tyrosine-regulated kinase 2 (DYRK2), a positive regulator of the 26S proteasome. Curcumin perturbs 26S proteasome activity via DYRK2 inhibition in various cancer cells and in the mouse cancer model leading to impairment of cell proliferation and reduction of cancer burden in mice. This novel mechanism of action of curcumin opens up new avenues for potential preventative or therapeutic strategies in proteasome-addicted cancers like triple-negative breast cancer and multiple myeloma.
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Cites
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
The Essential Medicinal Chemistry of Curcumin
Nelson, K. M., Dahlin, J. L., Bisson, J., Graham, J., Pauli, G. F., & Walters, M. A. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00975 · Cited by 1,956
The logic of the 26S proteasome.
Collins, G. A., & Goldberg, A. L. (2017) · Cell · doi:10.1016/j.cell.2017.04.023 · Cited by 933
Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction
Tai, H.-C., & Schuman, E. M. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2499 · Cited by 532
RPN-6 determines C. elegans longevity under proteotoxic stress conditions
Vilchez, D., Morantte, I., Liu, Z., Douglas, P. M., Merkwirth, C., Rodrigues, A. P. C., Manning, G., & Dillin, A. (2012) · Nature · doi:10.1038/nature11315 · Cited by 413
Increased proteasome activity in human embryonic stem cells is regulated by PSMD11
Vilchez, D., Boyer, L., Morantte, I., Lutz, M., Merkwirth, C., Joyce, D., Spencer, B., Page, L., Masliah, E., Berggren, W. T., et al. (2012) · Nature · doi:10.1038/nature11468 · Cited by 388
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Plant-Derived Anticancer Compounds as New Perspectives in Drug Discovery and Alternative Therapy
Dehelean, C. A., Marcovici, I., Soica, C., Mioc, M., Coricovac, D., Iurciuc, S., Cretu, O. M., & Pinzaru, I. (2021) · Molecules · doi:10.3390/molecules26041109 · Cited by 502
Zhu, Y., Ouyang, Z., Du, H., Wang, M., Wang, J., Sun, H., Kong, L., Xu, Q., Ma, H., & Sun, Y. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.08.022 · Cited by 414
Curcumin as an Alternative Epigenetic Modulator: Mechanism of Action and Potential Effects
Hassan, F.-U., Rehman, M. S.-U., Khan, M. S., Ali, M. A., Javed, A., Nawaz, A., & Yang, C. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00514 · Cited by 357
VerPlank, J. J. S., Lokireddy, S., Zhao, J., & Goldberg, A. L. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1809254116 · Cited by 122
Cuinat, S., Bézieau, S., Deb, W., Mercier, S., Vignard, V., Isidor, B., Küry, S., & Ebstein, F. (2024) · Genes & Diseases · doi:10.1016/j.gendis.2023.101130 · Cited by 10
Metadata
- Authors
- Banerjee, S., Ji, C., Mayfield, J. E., Goel, A., Xiao, J., Dixon, J. E., & Guo, X.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2018-07-09
- Volume
- 115
- Issue
- 32
- Pages
- 8155-8160
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2861982167
- Cited by
- 174
- References
- 6
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Banerjee, S., Ji, C., Mayfield, J. E., Goel, A., Xiao, J., Dixon, J. E., & Guo, X. (2018). Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1806797115
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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