The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4
Open accessAbstract
Substantial evidence supports the familial aggregation of exceptional longevity. The existence of rare families demonstrating clustering for this phenotype suggests that a genetic etiology may be an important component. Previous attempts at localizing loci predisposing for exceptional longevity have been limited to association studies of candidate gene polymorphisms. In this study, a genome-wide scan for such predisposing loci was conducted by using 308 individuals belonging to 137 sibships demonstrating exceptional longevity. By using nonparametric analysis, significant evidence for linkage was noted for chromosome 4 at D4S1564 with a MLS of 3.65 ( P = 0.044). The analysis was corroborated by a parametric analysis ( P = 0.052). These linkage results indicate the likelihood that there exists a gene, or genes, that exerts a substantial influence on the ability to achieve exceptional old age. Identification of the genes in humans that allow certain individuals to live to extreme old age should lead to insights on cellular pathways that are important to the aging process.
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Cites
Genetic associations with human longevity at the APOE and ACE loci
Schächter, F., Faure-Delanef, L., Guénot, F., Rouger, H., Froguel, P., Lesueur-Ginot, L., & Cohen, D. (1994) · Nature Genetics · doi:10.1038/ng0194-29 · Cited by 1,095
Cited by
Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue
Blüher, M., Kahn, B. B., & Kahn, C. R. (2003) · Science · doi:10.1126/science.1078223 · Cited by 1,155
The quest for genetic determinants of human longevity: challenges and insights
Christensen, K., Johnson, T. E., & Vaupel, J. W. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1871 · Cited by 489
Gerisch, B., Weitzel, C., Kober-Eisermann, C., Rottiers, V., & Antebi, A. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00085-5 · Cited by 395
Genetics of healthy aging and longevity
Brooks-Wilson, A. R. (2013) · Human Genetics · doi:10.1007/s00439-013-1342-z · Cited by 380
T cells and aging january 2002 update
Pawelec, G. (2002) · Frontiers in Bioscience · doi:10.2741/a831 · Cited by 369
Metadata
- Authors
- Puca, A. A., Daly, M. J., Brewster, S. J., Matise, T. C., Barrett, J., Shea-Drinkwater, M., Kang, S., Joyce, E., Nicoli, J., Benson, E., Kunkel, L. M., & Perls, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-08-27
- Volume
- 98
- Issue
- 18
- Pages
- 10505-10508
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2137048190
- Cited by
- 347
- References
- 1
- FWCI
- 16.74
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4. https://app.cochat.ai/papers/10.1073/pnas.181337598
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- Puca, A. A., Daly, M. J., Brewster, S. J., Matise, T. C., Barrett, J., Shea-Drinkwater, M., Kang, S., Joyce, E., Nicoli, J., Benson, E., Kunkel, L. M., & Perls, T. (2001). A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.181337598
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