The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
Spontaneous driving forces give rise to protein−RNA condensates with coexisting phases and complex material properties
Open accessAbstract
Significance: Biomolecular condensates comprise multiple protein and RNA molecules that are typically organized into complex, multilayered structures. Although recent studies have shown that multilayered condensates can arise spontaneously, the interactions that drive the spontaneous transitions remain unclear. Further, can molecules within the same layer have different dynamical properties or do such complex features require inputs of energy? Here, we report results from in vitro studies, which show that coexisting liquid- and solid-like material properties and multilayered architectures can result from spontaneous, sequence-encoded driving forces. Our studies, which are directed at the simplest biologically relevant protein and RNA sequences, suggest that spontaneous processes make key contributions to the formation of condensates with complex morphologies and diverse material properties.
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Cited by
The nucleolus as a multiphase liquid condensate
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Metadata
- Authors
- Boeynaems, S., Holehouse, A. S., Weinhardt, V., Kovacs, D., Van Lindt, J., Larabell, C., Van Den Bosch, L., Das, R., Tompa, P. S., Pappu, R. V., & Gitler, A. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2019-03-29
- Volume
- 116
- Issue
- 16
- Pages
- 7889-7898
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2905220927
- Cited by
- 482
- References
- 77
- FWCI
- 17.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Boeynaems, S., Holehouse, A. S., Weinhardt, V., Kovacs, D., Van Lindt, J., Larabell, C., Van Den Bosch, L., Das, R., Tompa, P. S., Pappu, R. V., & Gitler, A. D. (2019). Spontaneous driving forces give rise to protein−RNA condensates with coexisting phases and complex material properties. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1821038116
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