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Type III secretion systems and the evolution of mutualistic endosymbiosis
Open accessAbstract
The view that parasites can develop cooperative symbiotic relationships with their hosts is both appealing and widely held; however, there is no molecular genetic evidence of such a transition. Here we demonstrate that a mutualistic bacterial endosymbiont of grain weevils maintains and expresses inv / spa genes encoding a type III secretion system homologous to that used for invasion by bacterial pathogens. Phylogenetic analyses indicate that inv / spa genes were present in presymbiotic ancestors of the weevil endosymbionts, occurring at least 50 million years ago. The function of inv/spa genes in maintaining symbiosis is demonstrated by the up-regulation of their expression under both in vivo and in vitro conditions that coincide with host cell invasion.
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Cites
The Pleiotropic Two-Component Regulatory System PhoP-PhoQ
Groisman, E. A. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.6.1835-1842.2001 · Cited by 887
Cited by
A complex journey: transmission of microbial symbionts.
Bright, M., & Bulgheresi, S. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2262 · Cited by 894
Genome evolution in bacterial endosymbionts of insects
Wernegreen, J. J. (2002) · Nature Reviews Genetics · doi:10.1038/nrg931 · Cited by 487
From Parasite to Mutualist: Rapid Evolution of Wolbachia in Natural Populations of Drosophila
Weeks, A. R., Turelli, M., Harcombe, W. R., Reynolds, K. T., & Hoffmann, A. A. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050114 · Cited by 447
Metadata
- Authors
- Dale, C., Plague, G. R., Wang, B., Ochman, H., & Moran, N. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-09-04
- Volume
- 99
- Issue
- 19
- Pages
- 12397-12402
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2085594219
- Cited by
- 191
- References
- 1
- FWCI
- 21.74
- Type
- journal article
- Language
- en
- Open access
- green
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- Dale, C., Plague, G. R., Wang, B., Ochman, H., & Moran, N. A. (2002). Type III secretion systems and the evolution of mutualistic endosymbiosis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.182213299
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