The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Massively parallel screening of synthetic microbial communities
Open accessAbstract
Significance: Microbial communities have many applications, but current experimental strategies to investigate their behavior are limited by the combinatorial complexity of interactions between species. Here, we introduce a platform to automatically construct and test synthetic communities of microbes from a set of input species at a scale of ∼100,000 communities per day. As a first demonstration, we discovered specific compositions of bacteria isolated from local soil that promote the growth of a model plant symbiont. More broadly, our platform can be adopted for the discovery of microbial consortia with many useful properties, such as suppression of pathogens or degradation of recalcitrant substrates for use in biofuel production or environmental remediation.
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Citations
Cites
The rhizosphere microbiome and plant health
Berendsen, R. L., Pieterse, C. M. J., & Bakker, P. A. H. M. (2012) · Trends in Plant Science · doi:10.1016/j.tplants.2012.04.001 · Cited by 5,347
Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
Buffie, C. G., Bucci, V., Stein, R. R., McKenney, P. T., Ling, L., Gobourne, A., No, D., Liu, H., Kinnebrew, M., Viale, A., et al. (2015) · Nature · doi:10.1038/nature13828 · Cited by 1,872
The contribution of species richness and composition to bacterial services
Bell, T., Newman, J. A., Silverman, B. W., Turner, S. L., & Lilley, A. K. (2005) · Nature · doi:10.1038/nature03891 · Cited by 950
Community Structure Follows Simple Assembly Rules in Microbial Microcosms
Friedman, J., Higgins, L. M., & Gore, J. (2017) · Nature Ecology & Evolution · doi:10.1038/s41559-017-0109 · Cited by 557
Self-citationLawley, T. D., Clare, S., Walker, A. W., Stares, M. D., Connor, T. R., Raisen, C., Goulding, D., Rad, R., Schreiber, F., Brandt, C., et al. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002995 · Cited by 540
Microbial oxidation of lithospheric organic carbon in rapidly eroding tropical mountain soils
Hemingway, J. D., Hilton, R. G., Hovius, N., Eglinton, T. I., Haghipour, N., Wacker, L., Chen, M.-C., & Galy, V. V. (2018) · Science · doi:10.1126/science.aao6463 · Cited by 183
Cited by
Massively multiplexed nucleic acid detection with Cas13
Ackerman, C. M., Myhrvold, C., Thakku, S. G., Freije, C. A., Metsky, H. C., Yang, D. K., Ye, S. H., Boehm, C. K., Kosoko-Thoroddsen, T.-S. F., Kehe, J., et al. (2020) · Nature · doi:10.1038/s41586-020-2279-8 · Cited by 803
Self-citationMicrobiome Engineering: Synthetic Biology of Plant-Associated Microbiomes in Sustainable Agriculture
Ke, J., Wang, B., & Yoshikuni, Y. (2021) · Trends in Biotechnology · doi:10.1016/j.tibtech.2020.07.008 · Cited by 406
Recent Advances in Droplet Microfluidics
Ding, Y., Howes, P. D., & deMello, A. J. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.9b05047 · Cited by 357
Trophic Interactions and the Drivers of Microbial Community Assembly
Gralka, M., Szabo, R., Stocker, R., & Cordero, O. X. (2020) · Current Biology · doi:10.1016/j.cub.2020.08.007 · Cited by 331
Machine learning for metabolic engineering: A review
Lawson, C. E., Martí, J. M., Radivojevic, T., Jonnalagadda, S. V. R., Gentz, R., Hillson, N. J., Peisert, S., Kim, J., Simmons, B. A., Petzold, C. J., et al. (2021) · Metabolic Engineering · doi:10.1016/j.ymben.2020.10.005 · Cited by 313
Metadata
- Authors
- Kehe, J., Kulesa, A., Ortiz, A., Ackerman, C. M., Thakku, S. G., Sellers, D., Kuehn, S., Gore, J., Friedman, J., & Blainey, P. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2019-06-11
- Volume
- 116
- Issue
- 26
- Pages
- 12804-12809
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2953098897
- Cited by
- 263
- References
- 6
- FWCI
- 18.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kehe, J., Kulesa, A., Ortiz, A., Ackerman, C. M., Thakku, S. G., Sellers, D., Kuehn, S., Gore, J., Friedman, J., & Blainey, P. C. (2019). Massively parallel screening of synthetic microbial communities. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1900102116
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
