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Cited by 706

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Genome sequence of Halobacterium species NRC-1

Open access
Ng, Wailap Victor, Kennedy, Sean P., Mahairas, Gregory G., Berquist, Brian, Pan, Min, Shukla, Hem Dutt, Lasky, Stephen R., Baliga, Nitin S., Thorsson, Vesteinn, Sbrogna, Jennifer, Swartzell, Steven, Weir, Douglas, Hall, John, Dahl, Timothy A., Welti, Russell, Goo, Young Ah, Leithauser, Brent, Keller, Kim, Cruz, Randy, Danson, Michael J., Hough, David W., Maddocks, Deborah G., Jablonski, Peter E., Krebs, Mark P., Angevine, Christine M., Dale, Heather, Isenbarger, Thomas A., Peck, Ronald F., Pohlschroder, Mechthild, Spudich, John L., Jung, Kwang-Hwan, Alam, Maqsudul, Freitas, Tracey, Hou, Shaobin, Daniels, Charles J., Dennis, Patrick P., Omer, Arina D., Ebhardt, Holger, Lowe, Todd M., Liang, Ping, Riley, Monica, Hood, Leroy, DasSarma, Shiladitya·2000·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.190337797
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Abstract

We report the complete sequence of an extreme halophile, Halobacterium sp. NRC-1, harboring a dynamic 2,571,010-bp genome containing 91 insertion sequences representing 12 families and organized into a large chromosome and 2 related minichromosomes. The Halobacterium NRC-1 genome codes for 2,630 predicted proteins, 36% of which are unrelated to any previously reported. Analysis of the genome sequence shows the presence of pathways for uptake and utilization of amino acids, active sodium-proton antiporter and potassium uptake systems, sophisticated photosensory and signal transduction pathways, and DNA replication, transcription, and translation systems resembling more complex eukaryotic organisms. Whole proteome comparisons show the definite archaeal nature of this halophile with additional similarities to the Gram-positive Bacillus subtilis and other bacteria. The ease of culturing Halobacterium and the availability of methods for its genetic manipulation in the laboratory, including construction of gene knockouts and replacements, indicate this halophile can serve as an excellent model system among the archaea.

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Crossref · 10.1073/pnas.190337797

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Metadata

Authors
Ng, W. V., Kennedy, S. P., Mahairas, G. G., Berquist, B., Pan, M., Shukla, H. D., Lasky, S. R., Baliga, N. S., Thorsson, V., Sbrogna, J., Swartzell, S., Weir, D., Hall, J., Dahl, T. A., Welti, R., Goo, Y. A., Leithauser, B., Keller, K., Cruz, R., Danson, M. J., Hough, D. W., Maddocks, D. G., Jablonski, P. E., Krebs, M. P., Angevine, C. M., Dale, H., Isenbarger, T. A., Peck, R. F., Pohlschroder, M., Spudich, J. L., Jung, K.-H., Alam, M., Freitas, T., Hou, S., Daniels, C. J., Dennis, P. P., Omer, A. D., Ebhardt, H., Lowe, T. M., Liang, P., Riley, M., Hood, L., & DasSarma, S.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2000-10-03
Volume
97
Issue
22
Pages
12176-12181
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.190337797
OpenAlex
W2090438401
Cited by
706
References
49
FWCI
16.45
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Genome sequence of Halobacterium species NRC-1. https://app.cochat.ai/papers/10.1073/pnas.190337797
The paper
Ng, W. V., Kennedy, S. P., Mahairas, G. G., Berquist, B., Pan, M., Shukla, H. D., Lasky, S. R., Baliga, N. S., Thorsson, V., Sbrogna, J., Swartzell, S., Weir, D., Hall, J., Dahl, T. A., Welti, R., Goo, Y. A., Leithauser, B., Keller, K., Cruz, R., . . . DasSarma, S. (2000). Genome sequence of Halobacterium species NRC-1. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.190337797

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.