Cited by 640Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchSubstance Abuse Treatment and Outcomes

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ΔFosB: A sustained molecular switch for addiction

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Nestler, Eric J., Barrot, Michel, Self, David W.·2001·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.191352698PMC PMC58680

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Abstract

The longevity of some of the behavioral abnormalities that characterize drug addiction has suggested that regulation of neural gene expression may be involved in the process by which drugs of abuse cause a state of addiction. Increasing evidence suggests that the transcription factor ΔFosB represents one mechanism by which drugs of abuse produce relatively stable changes in the brain that contribute to the addiction phenotype. ΔFosB, a member of the Fos family of transcription factors, accumulates within a subset of neurons of the nucleus accumbens and dorsal striatum (brain regions important for addiction) after repeated administration of many kinds of drugs of abuse. Similar accumulation of ΔFosB occurs after compulsive running, which suggests that ΔFosB may accumulate in response to many types of compulsive behaviors. Importantly, ΔFosB persists in neurons for relatively long periods of time because of its extraordinary stability. Therefore, ΔFosB represents a molecular mechanism that could initiate and then sustain changes in gene expression that persist long after drug exposure ceases. Studies in inducible transgenic mice that overexpress either ΔFosB or a dominant negative inhibitor of the protein provide direct evidence that ΔFosB causes increased sensitivity to the behavioral effects of drugs of abuse and, possibly, increased drug seeking behavior. This work supports the view that ΔFosB functions as a type of sustained “molecular switch” that gradually converts acute drug responses into relatively stable adaptations that contribute to the long-term neural and behavioral plasticity that underlies addiction.

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Autoradiographic localization of dopamine D1 and D2 receptors in rat nucleus accumbens: Resistance to differential rearing conditions
Bardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,229
Molecular basis of long-term plasticity underlying addiction
Nestler, E. J. (2001) · Nature reviews. Neuroscience · doi:10.1038/35053570 · Cited by 1,893
Self-citation
Addiction, Dopamine, and the Molecular Mechanisms of Memory
Berke, J. D., & Hyman, S. E. (2000) · Neuron · doi:10.1016/s0896-6273(00)81056-9 · Cited by 1,184
Neuroscience of addiction
Koob, G. F., Sanna, P. P., & Bloom, F. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)80557-7 · Cited by 1,026
Amphetamine and cocaine induce drug-specific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatum.
Graybiel, A. M., Moratalla, R., & Robertson, H. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.17.6912 · Cited by 957
Regulation of cocaine reward by CREB
Carlezon, W. A., Thome, J., Olson, V. G., Lane-Ladd, S. B., Brodkin, E. S., Hiroi, N., Duman, R. S., Neve, R. L., & Nestler, E. J. (1998) · Science · doi:10.1126/science.282.5397.2272 · Cited by 767
Self-citation
Beyond the Dopamine Receptor
Greengard, P., Allen, P. B., & Nairn, A. C. (1999) · Neuron · doi:10.1016/s0896-6273(00)80798-9 · Cited by 761
Alterations in the morphology of dendrites and dendritic spines in the nucleus accumbens and prefrontal cortex following repeated treatment with amphetamine or cocaine
Robinson, T. E., & Kolb, B. E. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00576.x · Cited by 726
Drug-activation of brain reward pathways
Wise, R. A. (1998) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(98)00063-5 · Cited by 684
Synaptic plasticity and dynamic modulation of the postsynaptic membrane
Lüscher, C., Nicoll, R. A., Malenka, R. C., & Müller, D. (2000) · Nature Neuroscience · doi:10.1038/75714 · Cited by 662

Show all 45 references

Research works printed but not linked: 5

H Nye, B T Hope, M Kelz, M Iadarola, E J Nestler J Pharmacol Exp Ther 275, 1671–1680 (1995).
H E Nye, E J Nestler Mol Pharmacol 49, 636–645 (1996).
J S Chen, H E Nye, M B Kelz, N Hiroi, Y Nakabeppu, B T Hope, E J Nestler Mol Pharmacol 48, 880–889 (1995).
F J White, X-T Hu, X-F Zhang, M E Wolf J Pharmacol Exp Ther 273, 445–454 (1995).
M Carey, S T Smale Transcriptional Regulation in Eukaryotes (Cold Spring Harbor Lab. Press, Plainview, NY, 2000).

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Baldo, B. A., & Andrzejewski, M. E. (2009) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195373035.003.0021
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Works, C. A. (2014)
The effects of chronic partial sleep deprivation and chronic voluntary alcohol consumption on ΔFos B accumulation
Ponder, K. (2016) · JMU Scholoraly Commons (James Madison University)
Clinical Neuroscience of Substance Use Disorders
Hall, S. B., & Walker, K. D. (2017) · Wiley eBooks · doi:10.1002/9781119375487.ch9
Expression of messenger RNA (mRNA) for brain dopamine receptors and enkephalin before and after wheel running in rats selectively bred for high-and low- aerobic capacity
Monroe, D. C. (2011)
Evaluating Time-Dependent Changes in Food Seeking Following Periods of Forced Abstinence and Associated Changes in the Nucleus Accumbens
Tuplin, E. W. N. (2018) · Carleton University's Institutional Repository (MacOdrum Library, Carleton University) · doi:10.22215/etd/2018-13259
Young Adult and Middle-Age Rats Display Unique Working Memory Impairment and Differential Neurobiological Profiles following Hysterectomy
Woner, V. (2020)
From the Gut to the Brain: Hormonal Regulation of Brain Dopamine Homeostasis and Cocaine Reward
Reddy, I. A. (2016)
Smoking Mechanics and Impact on Smoking Cessation: Two Cases of Smoking Lapse Status Post Lung Transplantation
Galiatsatos, P., Ekpo, P., Schreiber, R., Barker, L., & Shah, P. (2022) · Tobacco Use Insights · doi:10.1177/1179173x211069634
Dopamine and ALK4 signaling synergize to induce PCBP1-mediated alternative splicing of FosB and sustained behavioral sensitization to cocainePreprint
Krapacher, F. A., Fernández‐Suárez, D., Andersson, A. K., Carrier‐Ruiz, A., & Ibáñez, C. F. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.20.477040
Psychostimulants
Howell, L. L., & Kimmel, H. L. (2007) · Wiley eBooks · doi:10.1002/9780470101001.hcn038
Adverse effects
Kumar, V. K. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90903-7.00009-0
Faculty Opinions recommendation of One is not enough: understanding and modeling polysubstance use.
Grunberg, N. E. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.738149771.793576347
Epidemiology of Substance use Disorders
Kandel, D. B., Hu, M., Griesler, P. C., Kerridge, B. T., & Grant, B. F. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780190681425.003.0041
DeltaFosB and Preclinical Binge Eating
Amissah, R. Q., & Timofeev, I. (2022) · Springer eBooks · doi:10.1007/978-3-030-67929-3_54-1
The role of ΔFosB in the plasticity of the cannabinoid system
Venebra-Muñoz, A., & Mejía-Chávez, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-89862-1.00019-2
Cell type-specific expression of the molecular players in mouse prefrontal cortex during cocaine addiction
Teng, E. (2023) · Highlights in Science Engineering and Technology · doi:10.54097/hset.v54i.9732
Medical Students' Internet Addiction And Its Impact On Academic AchievementPreprint
Al-Nahar, N., & Mardini, H. (2024) · Research Square · doi:10.21203/rs.3.rs-4117958/v1
Effects of Ayahuasca on Ethanol-Conditioned Place Preference and ΔFosB Expression in the Nucleus Accumbens in MicePreprint
Wiltenburg, V. D., Morales-Lima, G., Santos, A. V. S., Echeverry, M. B., Cruz, F. C., Silveira, G. D. O., Yonamine, M., Tiba, P. A., & Mendes, F. R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.07.592962
“It is a stable molecule that can remain present for long periods of time (Damez-Werno et al. 2012; Nestler et al. 2001) .”
Molecular mechanisms of cannabinergics
Maghembe, R. S., & Mtewa, A. G. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95927-8.00012-8
Reviewer #3 (Public Review): Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer
Barr, J., Walz, A., Restaino, A. C., et al. (2024) · eLife · doi:10.7554/elife.97916.2.sa1
eLife Assessment: Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer
Palmiter, R. D. (2024) · eLife · doi:10.7554/elife.97916.2.sa4
Reviewer #1 (Public Review): Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer
Barr, J., Walz, A., Restaino, A. C., et al. (2024) · eLife · doi:10.7554/elife.97916.2.sa3
Reviewer #2 (Public Review): Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer
Barr, J., Walz, A., Restaino, A. C., et al. (2024) · eLife · doi:10.7554/elife.97916.2.sa2
Author response: Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer
Barr, J. L., Walz, A., Restaino, A. C., Amit, M., Barclay, S. M., Vichaya, E. G., Spanos, W. C., Dantzer, R., Talbot, S., & Vermeer, P. D. (2024) · eLife · doi:10.7554/elife.97916.2.sa0
Effect of Alcohol and Cocaine Abuse on Neuronal and Non-Neuronal Cell Turnover in the Adult Human HippocampusPreprint
Alkass, K., Steiner, E., Bernard, S., Maître, T. W. L., Dhanabalan, G., Landén, M., Spalding, K. L., Frisén, J., Mash, D. C., & Druid, H. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.10.612190
“Learning and conditioning contributes to drug tolerance, dependence and relapse 16 and substance abuse is frequently associated with cognitive disorders, indicative of hippocampal dysfunction.”
Background
Cocaine, via ΔFosB, remodels gene expression and excitability in ventral hippocampusPreprint
Eagle, A. L., Doyle, M. A., Sugimoto, C., Dykstra, M. M., Kuhn, H. M., Murray, B. S., Bastle, R. M., He, J., Maze, I. S., Mazei‐Robison, M. S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.06.621895

Authors: Nestler, E. J., Barrot, M., & Self, D. W.
Affiliations: The University of Texas Southwestern Medical Center (US)
ORCID: Nestler, Eric J.
Barrot, Michel
Self, David W.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2001-09-25
Volume: 98
Issue: 20
Pages: 11042-11046
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.191352698
PMC: PMC58680
OpenAlex: W2000696407
Cited by: 640
References: 45
Citations by year: 2026: 24 · 2025: 32 · 2024: 41 · 2023: 31 · 2022: 27 · 2021: 30 · 2020: 17 · 2019: 25 · 2018: 23 · 2017: 23 · 2016: 24 · 2015: 22 · 2014: 17 · 2013: 29 · 2012: 27
FWCI: 1.91
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: ΔFosB, drug addiction, transcription factors, Fos family, nucleus accumbens, dorsal striatum, drug-seeking behavior, neuronal gene expression, behavioral plasticity, transgenic mice, protein stability
MeSH terms: Animals, Brain, Humans, Models, Neurological, Neurons, Proto-Oncogene Proteins c-fos, Genes, fos, Substance-Related Disorders

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ΔFosB: A sustained molecular switch for addiction

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