The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Biosynthesis and insecticidal properties of plant cyclotides: The cyclic knotted proteins from Oldenlandia affinis
Open accessAbstract
Several members of the Rubiaceae and Violaceae families produce a series of cyclotides or macrocyclic peptides of 29–31 amino acids with an embedded cystine knot. We aim to understand the mechanism of synthesis of cyclic peptides in plants and have isolated a cDNA clone that encodes the cyclotide kalata B1 as well as three other clones for related cyclotides from the African plant Oldenlandia affinis . The cDNA clones encode prepropeptides with a 20-aa signal sequence, an N-terminal prosequence of 46–68 amino acids and one, two, or three cyclotide domains separated by regions of about 25 aa. The corresponding cyclotides have been isolated from plant material, indicating that the cyclotide domains are excised and cyclized from all four predicted precursor proteins. The exact processing site is likely to lie on the N-terminal side of the strongly conserved GlyLeuPro or SerLeuPro sequence that flanks both sides of the cyclotide domain. Cyclotides have previously been assigned an antimicrobial function; here we describe a potent inhibitory effect on the growth and development of larvae from the Lepidopteran species Helicoverpa punctigera.
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Cites
Production of cyclic peptides and proteins in vivo
Scott, C. P., Abel-Santos, E., Wall, M., Wahnon, D. C., & Benkovic, S. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13638 · Cited by 402
Morton, R. L., Schroeder, H. E., Bateman, K. S., Chrispeels, M. J., Armstrong, E., & Higgins, T. J. V. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.070054597 · Cited by 262
Cited by
Arnison, P. G., Bibb, M. J., Bierbaum, G., Bowers, A. A., Bugni, T. S., Bulaj, G., Camarero, J. A., Campopiano, D. J., Challis, G. L., Clardy, J., et al. (2013) · Nat. Prod. Rep. · doi:10.1039/c2np20085f · Cited by 2,076
Self-citationPlant antimicrobial peptides: structures, functions, and applications
Li, J., Hu, S., Jian, W., Xie, C., & Yang, X. (2021) · Botanical Studies · doi:10.1186/s40529-021-00312-x · Cited by 312
Wang, C. K. L., Kaas, Q., Chiche, L., & Craik, D. J. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm953 · Cited by 295
Self-citationAlternative splicing: Enhancing ability to cope with stress via transcriptome plasticity
Mastrangelo, A. M., Marone, D., Laidò, G., De Leonardis, A. M., & De Vita, P. (2012) · Plant Science · doi:10.1016/j.plantsci.2011.09.006 · Cited by 277
Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase
Harris, K. S., Durek, T., Kaas, Q., Poth, A. G., Gilding, E. K., Conlan, B. F., Saska, I., Daly, N. L., van der Weerden, N. L., Craik, D. J., et al. (2015) · Nature Communications · doi:10.1038/ncomms10199 · Cited by 257
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Metadata
- Authors
- Jennings, C., West, J., Waine, C., Craik, D., & Anderson, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-09-04
- Volume
- 98
- Issue
- 19
- Pages
- 10614-10619
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2049202410
- Cited by
- 523
- References
- 2
- FWCI
- 9.07
- Type
- journal article
- Language
- en
- Open access
- green
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- Jennings, C., West, J., Waine, C., Craik, D., & Anderson, M. (2001). Biosynthesis and insecticidal properties of plant cyclotides: The cyclic knotted proteins from Oldenlandia affinis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.191366898
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