The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Expression of the integrin αEβ7identifies unique subsets of CD25+as well as CD25−regulatory T cells
Open accessAbstract
Regulatory CD25+CD4+T cells are considered as important players in T cell homeostasis and self-tolerance. Here we report that the integrin α E β 7, which recognizes epithelial cadherin, identifies the most potent subpopulation of regulatory CD25+T cells. Strikingly, CD25-negative α E+CD4+T cells displayed regulatory activity. Both α E+subsets, CD25+and CD25−, express CTLA-4, suppress T cell proliferation in vitro, and protect mice from colitis in the severe combined immunodeficient model (SCID)in vivo. Whereas α E+CD25+T cells produce almost no cytokines, α E+CD25−T cells represent a unique subset in which high IL-2, IFN-γ and T helper 2-cytokine production is linked with suppressive function. Thus, the integrin α E β 7 can be regarded as a novel marker for subsets of highly potent, functionally distinct regulatory T cells specialized for crosstalk with epithelial environments.
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Park, J.-H., Adoro, S., Guinter, T., Erman, B., Alag, A. S., Catalfamo, M., Kimura, M. Y., Cui, Y., Lucas, P. J., Gress, R. E., et al. (2010) · Nature Immunology · doi:10.1038/ni.1840 · Cited by 5,835
Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., & Toda, M. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.3.1151 · Cited by 5,608
Interleukin-10-deficient mice develop chronic enterocolitis
Kühn, R., Löhler, J., Rennick, D., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,274
Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., et al. (1992) · Nature · doi:10.1038/359693a0 · Cited by 2,985
Thornton, A. M., & Shevach, E. M. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.2.287 · Cited by 2,639
Takahashi, T., Tagami, T., Yamazaki, S., Uede, T., Shimizu, J., Sakaguchi, N., Mak, T. W., & Sakaguchi, S. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.2.303 · Cited by 2,233
Read, S., Malmström, V., & Powrie, F. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.2.295 · Cited by 2,205
Salomon, B., Lenschow, D. J., Rhee, L., Ashourian, N., Singh, B., Sharpe, A., & Bluestone, J. A. (2000) · Immunity · doi:10.1016/s1074-7613(00)80195-8 · Cited by 2,081
Sakaguchi, S. (2000) · Cell · doi:10.1016/s0092-8674(00)80856-9 · Cited by 1,815
Kägi, D., Ledermann, B., Bürki, K., Seiler, P., Odermatt, B., Olsen, K. J., Podack, E. R., Zinkernagel, R. M., & Hengartner, H. (1994) · Nature · doi:10.1038/369031a0 · Cited by 1,757
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Geuking, M. B., Cahenzli, J., Lawson, M. A. E., Ng, D. C. K., Slack, E., Hapfelmeier, S., McCoy, K. D., & Macpherson, A. J. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.021 · Cited by 840
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Metadata
- Authors
- Lehmann, J., Huehn, J., de la Rosa, M., Maszyna, F., Kretschmer, U., Krenn, V., Brunner, M., Scheffold, A., & Hamann, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-09-19
- Volume
- 99
- Issue
- 20
- Pages
- 13031-13036
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1619186743
- Cited by
- 454
- References
- 57
- FWCI
- 11.48
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Expression of the integrin αEβ7identifies unique subsets of CD25+as well as CD25−regulatory T cells. https://app.cochat.ai/papers/10.1073/pnas.192162899
- The paper
- Lehmann, J., Huehn, J., de la Rosa, M., Maszyna, F., Kretschmer, U., Krenn, V., Brunner, M., Scheffold, A., & Hamann, A. (2002). Expression of the integrin αEβ7identifies unique subsets of CD25+as well as CD25−regulatory T cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.192162899
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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