EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

Kleer, Celina G., Cao, Qi, Varambally, Sooryanarayana, Shen, Ronglai, Ota, Ichiro, Tomlins, Scott A., Ghosh, Debashis, Sewalt, Richard G. A. B., Otte, Arie P., Hayes, Daniel F., Sabel, Michael S., Livant, Donna, Weiss, Stephen J., Rubin, Mark A., Chinnaiyan, Arul M.·2003·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1933744100

Cited by (1,000)

Items 701–800 of 1,000

The Polycomb Group Protein EZH2 Impairs DNA Damage Repair Gene Expression in Human Uterine Fibroids1
Qiwei Yang, Sangeeta Nair, Archana Laknaur, Nahed Ismail, Michael P. Diamond, Ayman A. Al-Hendy · 2016 · Biology of Reproduction
Integrative Epigenetic and Gene Expression Analysis of Renal Tumor Progression to Metastasis
Hyeyoung Nam, Darshan Shimoga Chandrashekar, Anirban Kundu, Sandeep Balu Shelar, Eun-Young Kho, Guru Sonpavde, Gurudatta Naik, Pooja Ghatalia, Carolina Becker Livi, Sooryanarayana Varambally et al. · 2018 · Molecular Cancer Research
EZH2 Is Overexpressed in BRCA1 -like Breast Tumors and Predictive for Sensitivity to High-Dose Platinum-Based Chemotherapy
Julian Puppe, Mark Opdam, Philip C. Schouten, Katarzyna Jóźwiak, Esther H. Lips, Tesa Severson, Marieke van de Ven, Chiara Svetlana Brambillasca, Peter Bouwman, Olaf van Tellingen et al. · 2019 · Clinical Cancer Research
Biology of Polycomb and Trithorax Group Proteins
Achim Breiling, Luca Sessa, Valerio Orlando · 2007 · International review of cytology
Whole Transcriptome Amplification for Gene Expression Profiling and Development of Molecular Archives
Scott A. Tomlins, Rohit Mehra, Daniel R. Rhodes, Rajal B. Shah, Mark A. Rubin, Eric Bruening, Vladimir Makarov, Arul M. Chinnaiyan · 2006 · Neoplasia
Identification of cellular targets for the human papillomavirus E6 and E7 oncogenes by RNA interference and transcriptome analyses
Ruprecht Kuner, Markus Vogt, Holger Sültmann, Andreas Buneß, Susanne Dymalla, Julia Bulkescher, Mark Fellmann, Karin Butz, Annemarie Poustka, Felix Hoppe‐Seyler · 2007 · Journal of Molecular Medicine
Design, Synthesis, and Biological Evaluation of a Potent Dual EZH2–BRD4 Inhibitor for the Treatment of Some Solid Tumors
Niannian Huang, Ping Sung Liao, Yunxia Zuo, Lidan Zhang, Ruotian Jiang · 2023 · Journal of Medicinal Chemistry
Epigenetic factor EPC1 is a master regulator of DNA damage response by interacting with E2F1 to silence death and activate metastasis-related gene signatures
Yajie Wang, Vijay Alla, Deborah Goody, Shailendra K. Gupta, Alf Spitschak, Olaf Wolkenhauer A, Brigitte M. Pützer, David Engelmann · 2015 · Nucleic Acids Research
A potential antitumor ellagitannin, davidiin, inhibited hepatocellular tumor growth by targeting EZH2
Yan Wang, Jingyi Ma, Sheung Ching Chow, Chi Han Li, Zhangang Xiao, Ru Feng, Jie Fu, Yangchao Chen · 2013 · Tumor Biology
EZH2 inhibitors transcriptionally upregulate cytotoxic autophagy and cytoprotective unfolded protein response in human colorectal cancer cells.
Yao‐Yu Hsieh, Hsiang-Ling Lo, Pei‐Ming Yang · 2016 · Europe PMC (PubMed Central)
Regulation and role of post-translational modifications of enhancer of zeste homologue 2 in cancer development.
Haiqi Lu, Guangliang Li, Chenyi Zhou, Wei Jin, Xiaoling Qian, Zejing Wang, Hongming Pan, Hongchuan Jin, Xian Wang · 2016 · PubMed Central
Polycomb Repressor Complex 2 in Genomic Instability and Cancer
Zoe Veneti, Kalliopi K. Gkouskou, Aristides G. Eliopoulos · 2017 · International Journal of Molecular Sciences
Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities
Michela Serresi, Bjørn Siteur, Danielle Hulsman, Matthias Jürgen Schmitt, Cor Lieftink, Ben Morris, Matteo Cesaroni, Natalie Proost, Roderick L. Beijersbergen, Maarten van Lohuizen et al. · 2018 · The Journal of Experimental Medicine
Resveratrol inhibits the proliferation of estrogen receptor-positive breast cancer cells by suppressing EZH2 through the modulation of ERK1/2 signaling
Chunyan Hu, Yun Liu, Mengying Teng, Kailin Jiao, Jing Zhen, Maoxuan Wu, Zhong Li · 2019 · Cell Biology and Toxicology
Beyond EZH2: is the polycomb protein CBX2 an emerging target for anti-cancer therapy?
Maïka Jangal, Benjamin Lebeau, Michael Witcher · 2019 · Expert Opinion on Therapeutic Targets
Structural integrity and expression of the L3MBTL gene in normal and malignant hematopoietic cells
Donal MacGrogan, Nagesh Kalakonda, Sara Álvarez, Joseph Michael Scandura, Piernicola Boccuni, Bertil Johansson, Stephen D. Nimer · 2004 · Genes Chromosomes and Cancer
Long-Chain Fatty Acid Analogues Suppress Breast Tumorigenesis and Progression
Udi Gluschnaider, Rachel Hertz, Sarit Ohayon, Elia Smeir, Martha Smets, Eli Pikarsky, Jacob Bar‐Tana · 2014 · Cancer Research
Potential Epigenetic Mechanism(s) Associated With the Persistence of Psychoneurological Symptoms in Women Receiving Chemotherapy for Breast Cancer
Debra Lyon, Lynne W. Elmore, Noran Aboalela, Jacqueline C. Merrill, Nancy L. McCain, Angela Renee Starkweather, Ronald K. Elswick, Colleen K. Jackson‐Cook · 2013 · Biological Research For Nursing
Role of epigenetic mechanisms in epithelial-to-mesenchymal transition of breast cancer cells
Annina Nickel, Sonja C. Stadler · 2014 · Translational research
Differentiation and Loss of Malignant Character of Spontaneous Pulmonary Metastases in Patient-Derived Breast Cancer Models
Jessica Bockhorn, Aleix Prat, Ya-Fang Chang, Xia Liu, Simo Huang, Meng Shang, Chika Nwachukwu, Maria J. Gomez-Vega, Joshua Chuck Harrell, Olufunmilayo Ibironke Olopade et al. · 2014 · Cancer Research
The Transcriptional Repressor ZBTB4 Regulates EZH2 Through a MicroRNA-ZBTB4-Specificity Protein Signaling Axis
Won Seok Yang, Gayathri Chadalapaka, Sung‐Gook Cho, Syng‐Ook Lee, Un-Ho Jin, Indira Jutooru, Kwangmin Choi, Yuet‐Kin Leung, Shuk‐Mei Ho, Stephen H Safe et al. · 2014 · Neoplasia
MicroRNAs regulate KDM5 histone demethylases in breast cancer cells
Hélène Denis, Olivier Van Grembergen, Benjamin Delatte, Sarah Dedeurwaerder, Pascale Putmans, Emilie Calonne, Françoise Rothé, Christos P. Sotiriou, François Fuks, Rachel Deplus · 2015 · Molecular BioSystems
Histone deacetylase inhibitor sodium butyrate suppresses proliferation and promotes apoptosis in osteosarcoma cells by regulation of the MDM2–p53 signaling
Chuhai Xie, Boyi Wu, Binwei Chen, Qunwei Shi, Jianhong Guo, Ziwen Fan, Yan Huang · 2016 · OncoTargets and Therapy
Silencing Of hsa_circ_0008450 Represses Hepatocellular Carcinoma Progression Through Regulation Of microRNA-214-3p/EZH2 Axis
Tianyu Lin, Yi Dai, Xinli Guo, Wenchao Chen, Jiangang Zhao, Liping Cao, Zhengrong Wu · 2019 · Cancer Management and Research
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2–EED Interaction
Daohai Du, Dandan Xu, Licheng Zhu, Giulia Stazi, Clemens Zwergel, Yanli Liu, Zhongyuan Luo, Yuan‐Qing Li, Yuanyuan Zhang, Kongkai Zhu et al. · 2021 · Journal of Medicinal Chemistry
The epigenetics of breast cancer – Opportunities for diagnostics, risk stratification and therapy
Rieke Schröder, Anna Lena Illert, Thalia Erbes, Christian Flotho, Michael Lübbert, Jesús Duque‐Afonso · 2021 · Epigenetics
Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer
Pauliina Munne, Lahja Martikainen, Iiris Räty, Kia Bertula, Nonappa Nonappa, Janika Ruuska, Hanna Ala-Hongisto, Aino Peura, Babette Hollmann, Lilya Euro et al. · 2021 · Nature Communications
Enhancing the antitumor activity of ErbB blockade with histone deacetylase (HDAC) inhibition
Prakash Chinnaiyan, Sooryanarayana Varambally, Scott A. Tomlins, Soma S. Ray, Shyhmin Huang, Arul M. Chinnaiyan, Paul M. Harari · 2005 · International Journal of Cancer
PHF19 and Akt control the switch between proliferative and invasive states in melanoma
Stéphanie Ghislin, Frédérique Deshayes, Sandrine Middendorp, Nicole Boggetto, Catherine Alcaïde‐Loridan · 2012 · Cell Cycle
Dysregulated Recruitment of the Histone Methyltransferase EZH2 to the Class II Transactivator (CIITA) Promoter IV in Breast Cancer Cells
Agnieszka Dorota Truax, Meghna Thakkar, Susanna Fletcher Greer · 2012 · PLoS ONE
Tipping the lysine methylation balance in disease
Joshua C. Black, Johnathan R. Whetstine · 2012 · Biopolymers
Progesterone receptor activation downregulates GATA3 by transcriptional repression and increased protein turnover promoting breast tumor growth
Franco Izzo, Maria Florencia Mercogliano, Leandro Venturutti, Mercedes Tkach, Gloria Inurrigarro, Roxana Schillaci, Leandro C. A. Cerchietti, Patricia V. Elizalde, Cecilia Jazmín Proietti · 2014 · Breast Cancer Research
Global Epigenetic Profiling In Bladder Cancer
Ewa Dudziec, John R. Goepel, James W.F. Catto · 2011 · Epigenomics
The Polycomb Repressive Complex 1 Protein BMI1 Is Required for Constitutive Heterochromatin Formation and Silencing in Mammalian Somatic Cells
Mohamed Abdouh, Roy Hanna, Jida El Hajjar, Anthony Flamier, Gilbert Bernier · 2015 · Journal of Biological Chemistry
BRCA1 positively regulates FOXO3 expression by restricting FOXO3 gene methylation and epigenetic silencing through targeting EZH2 in breast cancer
Chun Gong, Shilin Yao, Ana Gomes, Ellen P.S. Man, Heon‐Jin Lee, Gyungyub Gong, Suhwan Chang, S-B. Kim, K Fujino, S-W. Kim et al. · 2016 · Oncogenesis
Setdb1, a novel interactor of ΔNp63, is involved in breast tumorigenesis
Carla Regina, Mirco Compagnone, Angelo Peschiaroli, Anna Maria Lena, Margherita Annicchiarico‐Petruzzelli, Maria Cristina Piro, Gerry Melino, Eleonora Candi · 2016 · Oncotarget
EZH2 and histone deacetylase inhibitors induce apoptosis in triple negative breast cancer cells by differentially increasing H3 Lys27 acetylation in the BIM gene promoter and enhancers
Julia Huang, Kun Ling · 2017 · Oncology Letters
CENPL, ISG20L2, LSM4, MRPL3 are four novel hub genes and may serve as diagnostic and prognostic markers in breast cancer
Jinbao Yin, Chen Lin, Meng Jiang, Xinbin Tang, Danlin Xie, Jingwen Chen, Rongqin Ke · 2021 · Scientific Reports
Regulation of Stem Cell Differentiation by Histone Methyltransferases and Demethylases
Diego Pasini, Adrian P. Bracken, Karl Agger, Jesper Frank Christensen, Klaus H. Hansen, Paul A. Cloos, Kristian Helin · 2008 · Cold Spring Harbor Symposia on Quantitative Biology
Independent prognostic value of the basal‐like phenotype of breast cancer and associations with EGFR and candidate stem cell marker BMI‐1
Jarle B. Arnes, Karin Collett, Lars A. Akslen · 2008 · Histopathology
SET domain-containing Protein 4 (SETD4) is a Newly Identified Cytosolic and Nuclear Lysine Methyltransferase involved in Breast Cancer Cell Proliferation
Jerusa Araújo Quintão Arantes Faria · 2013 · Journal of Cancer Science & Therapy
Carcinogenesis of Intraductal Papillary Mucinous Neoplasm of the Pancreas: Loss of MicroRNA-101 Promotes Overexpression of Histone Methyltransferase EZH2
Osamu Nakahara, Hiroshi Takamori, Masaaki Iwatsuki, Yoshifumi Baba, Yasuo Sakamoto, Hiroshi Tanaka, Akira Chikamoto, Kei Horino, Toru Beppu, Keiichiro Kanemitsu et al. · 2011 · Annals of Surgical Oncology
The roles of ncRNAs and histone-modifiers in regulating breast cancer stem cells
Zhiju Zhao, Shu Li, Erwei Song, Suling Liu · 2015 · Protein & Cell
High EZH2 Protein Expression Is Associated with Poor Overall Survival in Patients with Luminal A Breast Cancer
Si‐Hyong Jang, Jong Eun Lee, Mee‐Hye Oh, Ji‐Hye Lee, Hyun Deuk Cho, Kyung-Ju Kim, Sung Yong Kim, Sun Wook Han, Han Jo Kim, Sang Byung Bae et al. · 2016 · Journal of Breast Cancer
Expression of EZH2 is associated with poor outcome in colorectal cancer
Zhuanpeng Chen, Ping Yang, Wanglin Li, Feng He, Jianchang Wei, Tong Zhang, Junbin Zhong, Huacui Chen, Jie Cao · 2017 · Oncology Letters
The Methylation Status of the Epigenome: Its Emerging Role in the Regulation of Tumor Angiogenesis and Tumor Growth, and Potential for Drug Targeting
Luciano Pirola, Oskar Ciesielski, Aneta Balcerczyk · 2018 · Cancers
Protein Quantification and Imaging by Surface‐Enhanced Raman Spectroscopy and Similarity Analysis
Hyunku Shin, Seunghyun Oh, Daehyeon Kang, Yeonho Choi · 2020 · Advanced Science
Targeting Histone Modifications in Breast Cancer: A Precise Weapon on the Way
Wei Li, Hao Wu, Shiyao Sui, Qin Wang, Shouping Xu, Da Pang · 2021 · Frontiers in Cell and Developmental Biology
Chromatin Remodeling in Mammary Gland Differentiation and Breast Tumorigenesis
Tim H.‐M. Huang, Manel Esteller · 2010 · Cold Spring Harbor Perspectives in Biology
Overexpression of EZH2/NSD2 Histone Methyltransferase Axis Predicts Poor Prognosis and Accelerates Tumor Progression in Triple-Negative Breast Cancer
Bo Gao, Xiumin Liu, Zhengjin Li, Lixian Zhao, Yun Pan · 2021 · Frontiers in Oncology
Hypothesis: Activation of rapid signaling by environmental estrogens and epigenetic reprogramming in breast cancer
Lindsey S. Treviño, Quan Wang, Cheryl Lyn Walker · 2014 · Reproductive Toxicology
Epigenetic Mechanisms in Commonly Occurring Cancers
Lauren P. Blair, Qin Yan · 2012 · DNA and Cell Biology
High expression of Polycomb group protein EZH2 predicts poor survival in salivary gland adenoid cystic carcinoma
Hedy Vékony, Frank M. Raaphorst, Arie P. Otte, Maarten van Lohuizen, Charles René Leemans, Isaäc van der Waal, Elisabeth Bloemena · 2008 · Journal of Clinical Pathology
Inhibitors of Emerging Epigenetic Targets for Cancer Therapy: a Patent Review (2010–2014)
Minoru Tanaka, Justin M. Roberts, Jun Qi, James E. Bradner · 2015 · Pharmaceutical Patent Analyst
A Tox21 Approach to Altered Epigenetic Landscapes: Assessing Epigenetic Toxicity Pathways Leading to Altered Gene Expression and Oncogenic Transformation In Vitro
Craig L.J. Parfett, Daniel M. Desaulniers · 2017 · International Journal of Molecular Sciences
LncRNA-ANCR regulates the cell growth of osteosarcoma by interacting with EZH2 and affecting the expression of p21 and p27
Fei Zhang, Hao Peng · 2017 · Journal of Orthopaedic Surgery and Research
miR‑92b promotes autophagy and suppresses viability and invasion in breast cancer by targeting EZH2
Fei Liu, Meixiang Sang, Lingjiao Meng, Lina Gu, Shina Liu, Juan Li, Cuizhi Geng · 2018 · International Journal of Oncology
Reduction of Global H3K27me3 Enhances HER2/ErbB2 Targeted Therapy
Alison Hirukawa, Salendra Singh, Jarey H. Wang, Jonathan P. Rennhack, Matthew Swiatnicki, Virginie Sanguin‐Gendreau, Dongmei Zuo, Kamilia Daldoul, Cynthia A. Lavoie, Morag Park et al. · 2019 · Cell Reports
The molecular mechanisms and therapeutic potential of EZH2 in breast cancer
Sara Adibfar, Marischa Elveny, Hadisha Sh. Kashikova, Maria Vladimirovna Mikhailova, Pooya Farhangnia, Sajjad Vakili‐Samiani, Hanieh Tarokhian, Farhad Jadidi‐Niaragh · 2021 · Life Sciences
The polycomb group proteins, BMI-1 and EZH2, are tumour-associated antigens
Jane C. Steele, Elizabeth Torr, Karen L. Noakes, Emma Kalk, Paul A. H. Moss, Gary M. Reynolds, Stefan G. Hübscher, Maarten van Lohuizen, David Adams, Lawrence S. Young · 2006 · British Journal of Cancer
Epigenetic modulation of antitumor immunity and immunotherapy response in breast cancer: biological mechanisms and clinical implications
Jun Yin, Tiezheng Gu, Norin Yasin Chaudhry, Nancy E. Davidson, Yi Huang · 2024 · Frontiers in Immunology
Oncogenic RAS alters the global and gene-specific histone modification pattern during epithelial–mesenchymal transition in colorectal carcinoma cells
Ignacio Mazón Peláez, Μαργαρίτα Καλογεροπούλου, Angelo Ferraro, Angeliki Voulgari, Tibor Pankotai, Imre Boros, Alexander Pintzas · 2010 · The International Journal of Biochemistry & Cell Biology
The Role of Chromatin in Molecular Mechanisms of Toxicity
Jonathan G. Moggs · 2004 · Toxicological Sciences
Comparison of Expression Profiles in Ovarian Epithelium In Vivo and Ovarian Cancer Identifies Novel Candidate Genes Involved in Disease Pathogenesis
Catherine Emmanuel, Natalie Gava, Catherine J. Kennedy, Rosemary L. Balleine, Raghwa N. Sharma, Gerard Wain, Alison H. Brand, Russell J. Hogg, Dariush Etemadmoghadam, Joshy George et al. · 2011 · PLoS ONE
The Role of Polycomb Repressive Complex in Malignant Peripheral Nerve Sheath Tumor
Xiyuan Zhang, Béga Murray, George Mo, Jack F. Shern · 2020 · Genes
Systematic search for the best gene expression markers for melanoma micrometastasis detection
Johanna Soikkeli, Margus Lukk, Pirjo Nummela, S Virolainen, Tiina Jahkola, Riku Katainen, LEENA M. HARJU, Esko Ukkonen, Olli Saksela, Erkki Hölttä · 2007 · The Journal of Pathology
Targeting cancer epigenetics: Linking basic biology to clinical medicine
Keiko Shinjo, Yutaka Kondo · 2015 · Advanced Drug Delivery Reviews
Enhancer of zeste homolog 2: A potential target for tumor therapy
Yongtao Xiao · 2011 · The International Journal of Biochemistry & Cell Biology
Prognostic impact of the cancer stem cell related markers ALDH1 and EZH2 in triple negative and basal-like breast cancers
Marina De Brot, Rafael Malagoli Rocha, Fernando Augusto Soares, Helenice Gobbi · 2012 · Pathology
Increased expression of EZH2 in Merkel cell carcinoma is associated with disease progression and poorer prognosis
Kelly L. Harms, Heather A. Chubb, Lili Zhao, Douglas Randall Fullen, Christopher Keram Bichakjian, Timothy M. Johnson, Shannon L. Carskadon, Nallasivam Palanisamy, Paul W. Harms · 2017 · Human Pathology
MicroRNA‑101‑3p inhibits proliferation in retinoblastoma cells by targeting EZH2 and HDAC9
Qifang Jin, Wenfeng He, Leifeng Chen, Yang Yang, Ke Shi, Zhipeng You · 2018 · Experimental and Therapeutic Medicine
EZH2-Mediated Epigenetic Suppression of GDF15 Predicts a Poor Prognosis and Regulates Cell Proliferation in Non-Small-Cell Lung Cancer
Xiyi Lu, Xuezhi He, Jun Su, Jing Wang, Xinyin Liu, Kun Xu, Wei De, Erbao Zhang, Renhua Guo, Yuenian Eric Shi · 2018 · Molecular Therapy — Nucleic Acids
Alteration of mammary gland development by bisphenol a and evidence of a mode of action mediated through endocrine disruption
Martine Perrot‐Applanat, Martine Kolf‐Clauw, Cécile Michel, Claire Beausoleil · 2018 · Molecular and Cellular Endocrinology
The Role of Polycomb Group Protein BMI1 in DNA Repair and Genomic Stability
Amira Mohammed Fitieh, Andrew J. Locke, Mobina Motamedi, Ismail Hassan Ismail · 2021 · International Journal of Molecular Sciences
Expression of EZH2 in renal cell carcinoma as a novel prognostic marker
Hye Won Lee, Misun Choe · 2012 · Pathology International
Theanine from tea and its semi-synthetic derivative TBrC suppress human cervical cancer growth and migration by inhibiting EGFR/Met-Akt/NF-κB signaling
Liu, Jiannan, Sun, Yuping, Zhang, Huarong, Ji, Dexin, Wu, Fei, Tian, Huihui, Liu, Kun, Zhang, Ying, Wu, Benhao, Zhang, Guoying · 2016 · European Journal of Pharmacology
RAS oncogenic signal upregulates EZH2 in pancreatic cancer
Fujii, Satoshi, Fukamachi, Katsumi, Tsuda, Hiroyuki, Ito, Kosei, Ito, Yoshiaki, Ochiai, Atsushi · 2012 · Biochemical and Biophysical Research Communications
Epigenetic regulation of skin: focus on the Polycomb complex
Jisheng Zhang, Evan Bardot, Elena Ezhkova · 2012 · Cellular and Molecular Life Sciences
EZH2 promotes a bi-lineage identity in basal-like breast cancer cells
Roy Zvi Granit, Yael Gabai, Tal Hadar, Yael Karamansha, L Liberman, Ithai Waldhorn, Irit Gat‐Viks, Aviv Regev, Bella Maly, Merav Darash‐Yahana et al. · 2012 · Oncogene
Expression of Polycomb Targets Predicts Breast Cancer Prognosis
Alba Jené-Sanz, Renáta Váraljai, Alexandra V. Vilkova, Galina F. Khramtsova, Andrey Khramtsov, Olufunmilayo Ibironke Olopade, Núria López-Bigas, Elizaveta V. Benevolenskaya · 2013 · Molecular and Cellular Biology
Long noncoding RNA cancer susceptibility candidate�9 promotes doxorubicin‑resistant breast cancer by binding to enhancer of zeste homolog 2
Baohong Jiang, Yuehua Li, Xiaofei Qu, Hongbo Zhu, Yeru Tan, Qun Fan, Yiling Jiang, Mingchu Liao, Xiaoping Wu · 2018 · International Journal of Molecular Medicine
SMARCB1 protein and mRNA loss is not caused by promoter and histone hypermethylation in epithelioid sarcoma
Gergő Papp, Yi-Che Changchien, Bálint Ferenc Péterfia, Loránd Pecsenka, Thomas N Krausz, Thomas P. Stricker, András Khoór, Ludvik R. Donner, Zoltàn Sápi · 2012 · Modern Pathology
Targeting Enhancer of Zeste Homolog 2 as a promising strategy for cancer treatment
Irene Marchesi, Luigi Bagella · 2016 · World Journal of Clinical Oncology
Exploring viral mimicry combined with epigenetics and tumor immunity: new perspectives in cancer therapy
Ruirui Wang, Xin Dong, Xiongjian Zhang, Jinzhuang Liao, Wei Cui, Wei Li · 2025 · International Journal of Biological Sciences
c-Rel Regulates Ezh2 Expression in Activated Lymphocytes and Malignant Lymphoid Cells
Wen Hao Neo, Jun Feng Lim, Raelene J. Grumont, Steve Gerondakis, I-hsin Su · 2014 · Journal of Biological Chemistry
Functional Crosstalk Between Lysine Methyltransferases on Histone Substrates: The Case of G9A/GLP and Polycomb Repressive Complex 2
Chiara Mozzetta, Julien Pontis, Slimane Ait‐Si‐Ali · 2014 · Antioxidants and Redox Signaling
EZH2 knockdown suppresses the growth and invasion of human inflammatory breast cancer cells
Zhaomei Mu, Hua Li, Sandra Viviana Fernandez, Katherine R. Alpaugh, Rugang Zhang, Massimo Cristofanilli · 2013 · Journal of Experimental & Clinical Cancer Research
GSK3β inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers
How‐Wen Ko, Heng‐Huan Lee, Longfei Huo, Weiya Xia, Cheng-Chieh Yang, Jennifer L. Hsu, Long‐Yuan Li, Chien‐Chen Lai, Li-Chuan Chan, Chien-Chia Cheng et al. · 2016 · Oncotarget
Potential application of cell reprogramming techniques for cancer research
Shigeo Saito, Ying‐Chu Lin, Yukio Nakamura, Richard Eckner, Kenly Wuputra, Kung‐Kai Kuo, Chang‐Shen Lin, Kazunari K. Yokoyama · 2018 · Cellular and Molecular Life Sciences
An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis
Harvey W. Smith, Alison Hirukawa, Virginie Sanguin‐Gendreau, Ipshita Nandi, Catherine R. Dufour, Dongmei Zuo, Kristofferson V. Tandoc, Matthew Leibovitch, Salendra Singh, Jonathan P. Rennhack et al. · 2019 · Nature Communications
NOTCH and EZH2 collaborate to repress PTEN expression in breast cancer
Kyrie Pappas, Tiphaine C. Martin, Andrew L. Wolfe, Christie B. Nguyen, Tao Su, Jian Jun Jin, Hanina H. Hibshoosh, Ramon E. Parsons · 2021 · Communications Biology
EZH2 as a mediator of treatment resistance in melanoma
Jessamy C. Tiffen, Stuart J. Gallagher, Hsin‐Yi Tseng, Fabian V. Filipp, Barbara Fazekas de St Groth, Peter Hersey · 2016 · Pigment Cell & Melanoma Research
Th22 cells control colon tumorigenesis through STAT3 and Polycomb Repression complex 2 signaling
Danfeng Sun, Yanwei Lin, Jie Hong, Haoyan Chen, Nisha Nagarsheth, Dongjun Peng, Shuang Wei, Emina H. Huang, Jing‐Yuan Fang, Ilona Kryczek et al. · 2015 · OncoImmunology
Increased EZH2 expression during the adenoma‑carcinoma sequence in colorectal cancer
Mayuko Ohuchi, Yasuo Sakamoto, Ryuma Tokunaga, Yuki Kiyozumi, Kenichi Nakamura, Daisuke Izumi, Keisuke Kosumi, Kazuto Harada, Junji Kurashige, Masaaki Iwatsuki et al. · 2018 · Oncology Letters
EZH2 and ALDH1 expression in ductal carcinoma in situ: Complex association with recurrence and progression to invasive breast cancer
Erik S. Knudsen, Agnes Witkiewicz · 2013 · Cell Cycle
H2AK119Ub1 and H3K27Me3 in molecular staging for survival prediction of patients with pancreatic ductal adenocarcinoma
Shi Chen, Jiangzhi Chen, Qian Zhan, Yi Zhu, Hao Chen, Xiaxing Deng, Zhaoyuan Hou, Baiyong Shen, Yanling Chen, Chenghong Peng · 2014 · Oncotarget
A miR-200c/141-BMI1 autoregulatory loop regulates oncogenic activity of BMI1 in cancer cells
Manjari Dimri, Mingu Kang, Goberdhan P. Dimri · 2016 · Oncotarget
Identifying Network Perturbation in Cancer
Maxim Grechkin, Benjamin A. Logsdon, Andrew J. Gentles, Su‐In Lee · 2016 · PLoS Computational Biology
Diosgenin exhibits tumor suppressive function via down-regulation of EZH2 in pancreatic cancer cells
Wenhao Guo, Yujia Chen, Jinsheng Gao, Kunhong Zhong, Heng Wei, Ke Li, Mei Tang, Xinyu Zhao, Xinyu Liu, Chunlai Nie et al. · 2019 · Cell Cycle
Long non-coding RNAs: Key regulators in oxaliplatin resistance of colorectal cancer
Fang-fang Qi, Yunyao Yang, Haowen Zhang, Hongping Chen · 2020 · Biomedicine & Pharmacotherapy