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Soluble HLA-G protein secreted by allo-specific CD4+T cells suppresses the allo-proliferative response: A CD4+T cell regulatory mechanism
Open accessAbstract
We recently reported that the nonclassical HLA class I molecule HLA-G was expressed in the endomyocardial biopsies and sera of 16% of heart transplant patients studied. The aim of the present report is to identify cells that may be responsible for HLA-G protein expression during the allogeneic reaction. Carrying out mixed lymphocyte cultures in which the responder cell population was depleted either in CD4+or CD8+T cells, we found that soluble HLA-G5 protein but not the membrane-bound HLA-G isoform was secreted by allo-specific CD4+T cells from the responder population, which suppressed the allogeneic proliferative T cell response. This inhibition may be reversed by adding the anti-HLA-G 87G antibody to a mixed lymphocyte culture. That may indicate a previously uncharacterized regulatory mechanism of CD4+T cell proliferative response.
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Cited by
Selmani, Z., Naji, A., Zidi, I., Favier, B., Gaiffe, E., Obert, L., Borg, C., Saas, P., Tiberghien, P., Rouas-Freiss, N., et al. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0554 · Cited by 1,081
Self-citationCarosella, E. D., Rouas-Freiss, N., Roux, D. T.-L., Moreau, P., & LeMaoult, J. (2015) · Advances in Immunology · doi:10.1016/bs.ai.2015.04.001 · Cited by 395
Self-citationContini, P., Ghio, M., Poggi, A., Filaci, G., Indiveri, F., Ferrone, S., & Puppo, F. (2003) · European Journal of Immunology · doi:10.1002/immu.200390015 · Cited by 358
Activation of NK Cells by an Endocytosed Receptor for Soluble HLA-G
Rajagopalan, S., Bryceson, Y. T., Kuppusamy, S. P., Geraghty, D. E., Meer, A. V. D., Joosten, I., & Long, E. O. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0040009 · Cited by 353
The role of the immune system in preeclampsia
Saito, S., Shiozaki, A., Nakashima, A., Sakai, M., & Sasaki, Y. (2007) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2007.02.006 · Cited by 351
Metadata
- Authors
- Lila, N., Rouas-Freiss, N., Dausset, J., Carpentier, A., & Carosella, E. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-09-25
- Volume
- 98
- Issue
- 21
- Pages
- 12150-12155
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2029488286
- Cited by
- 314
- References
- 0
- FWCI
- 5.02
- Type
- journal article
- Language
- en
- Open access
- green
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- Lila, N., Rouas-Freiss, N., Dausset, J., Carpentier, A., & Carosella, E. D. (2001). Soluble HLA-G protein secreted by allo-specific CD4+T cells suppresses the allo-proliferative response: A CD4+T cell regulatory mechanism. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.201407398
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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