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Two-dimensional IR spectroscopy can be designed to eliminate the diagonal peaks and expose only the crosspeaks needed for structure determination
Open accessAbstract
The power of two-dimensional (2D) IR spectroscopy as a structural method with unprecedented time resolution is greatly improved by the introduction of IR polarization conditions that completely eliminate diagonal peaks from the spectra and leave only the crosspeaks needed for structure determination. This approach represents a key step forward in the applications of 2D IR to proteins, peptides, and other complex molecules where crosspeaks are often obscured by diagonal peaks. The technique is verified on the model compound 1,3-cyclohexanedione and subsequently used to clarify the distribution of structures that the acetylproline-NH 2 dipeptide adopts in chloroform. In both cases, crosspeaks are revealed that were not observed before, which, in the case of the dipeptide, has led to additional information about the structure of the amino group end of the peptide.
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Cited by
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Jonas, D. M. (2003) · Annual Review of Physical Chemistry · doi:10.1146/annurev.physchem.54.011002.103907 · Cited by 1,198
Coherent Two-Dimensional Optical Spectroscopy
Cho, M. (2008) · Chemical Reviews · doi:10.1021/cr078377b · Cited by 835
Identification and characterization of diverse coherences in the Fenna–Matthews–Olson complex
Thyrhaug, E., Tempelaar, R., Alcocer, M. J. P., Žídek, K., Bína, D., Knoester, J., Jansen, T. L. C., & Zigmantas, D. (2018) · Nature Chemistry · doi:10.1038/s41557-018-0060-5 · Cited by 278
Metadata
- Authors
- Zanni, M. T., Ge, N.-H., Kim, Y. S., & Hochstrasser, R. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-09-18
- Volume
- 98
- Issue
- 20
- Pages
- 11265-11270
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2010253401
- Cited by
- 311
- References
- 0
- FWCI
- 11.08
- Type
- journal article
- Language
- en
- Open access
- green
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- Zanni, M. T., Ge, N.-H., Kim, Y. S., & Hochstrasser, R. M. (2001). Two-dimensional IR spectroscopy can be designed to eliminate the diagonal peaks and expose only the crosspeaks needed for structure determination. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.201412998
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