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Modulation of specific intestinal epithelial progenitors by enteric neurons
Open accessAbstract
The proglucagon-derived peptide glucagon-like peptide 2 (GLP-2), a product of a subset of gut epithelial cells, is pursued clinically for its ability to stimulate gut epithelial growth and repair. Here we show that although specific epithelial progenitors respond to GLP-2 administration, the epithelium does not express the GLP-2 receptor. Rather, enteric neurons express the receptor, respond to GLP-2, and transmit a signal (which can be blocked by the voltage-gated sodium channel inhibitor tetrodotoxin) back to the epithelium. Thus the nervous system is a key component of a feedback loop regulating epithelial growth and repair.
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“Indeed, GLP-2 receptors are present on enteric neurons in guinea pig ileum, mouse jejunum, mouse and pig intestine (20,51,52) and absorptive enterocyte progenitors in mouse jejunum respond to GLP-2 in an enteric neuron-dependent manner (52).”
From Gut mechanisms linking intestinal sweet sensing to glycemic control (2018) · cites this paper as [52]
Citations
Cites
Induction of c-fos-like protein in spinal cord neurons following sensory stimulation
Hunt, S. P., Pini, A., & Evan, G. I. (1987) · Nature · doi:10.1038/328632a0 · Cited by 1,986
Cheng, H., & Leblond, C. P. (1974) · American Journal of Anatomy · doi:10.1002/aja.1001410407 · Cited by 1,737
Self-citationW/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity
Hulzinga, J. D., Thuneberg, L., Klüppel, M., Malysz, J., Mikkelsen, H., & Bernstein, A. (1995) · Nature · doi:10.1038/373347a0 · Cited by 1,432
Lee, J. H., Kim, S.-Y., Kwon, Y. K., Kim, B. J., & So, I. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350075 · Cited by 1,380
Baynash, A. G., Hosoda, K., Giaid, A., Richardson, J., Emoto, N., Hammer, R., & Yanagisawa, M. (1994) · Cell · doi:10.1016/0092-8674(94)90018-3 · Cited by 974
Induction of intestinal epithelial proliferation by glucagon-like peptide 2.
Drucker, D. J., Erlich, P., Asa, S. L., & Brubaker, P. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.7911 · Cited by 888
Kim, B. J., Nam, J., Kim, K. H., Joo, M., Ha, T. S., Weon, K.-Y., Choi, S., Jun, J. Y., Park, E., Wie, J., et al. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000366306 · Cited by 886
Jeppesen, P. B., Hartmann, B., Thulesen, J., Graff, J., Lohmann, J., Hansen, B. S., Tofteng, F., Poulsen, S. S., Madsen, J. L., Holst, J. J., et al. (2001) · Gastroenterology · doi:10.1053/gast.2001.22555 · Cited by 532
Clonal analysis of mouse intestinal epithelial progenitors
Bjerknes, M., & Cheng, H. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70222-2 · Cited by 429
Self-citationFarrell, C. L., Bready, J. V., Rex, K. L., Chen, J. N., DiPalma, C., Whitcomb, K. L., Yin, S., Hill, D. C., Wiemann, B., Starnes, C. O., et al. (1998) · PubMed · Cited by 357
Enteroendocrine localization of GLP-2 receptor expression in humans and rodents
Yusta, B., Huang, L., Munroe, D. G., Wolff, G., Fantaske, R. P., Sharma, S., Demchyshyn, L. L., Asa, S. L., & Drucker, D. J. (2000) · Gastroenterology · doi:10.1053/gast.2000.16489 · Cited by 339
Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2
Munroe, D. G., Gupta, A., Kooshesh, F., Vyas, T., Rizkalla, G., Wang, H., Demchyshyn, L. L., Yang, Z., Kamboj, R. K., Chen, H., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1569 · Cited by 328
Regulation of the biological activity of glucagon-like peptide 2 in vivo by dipeptidyl peptidase IV
Drucker, D. J., Shi, Q., Crivici, A., Sumner-Smith, M., Tavares, W., Hill, M. E., DeForest, L., Cooper, S., & Brubaker, P. L. (1997) · Nature Biotechnology · doi:10.1038/nbt0797-673 · Cited by 278
Benjamin, M. A., McKay, D. M., Yang, P.-C., Cameron, H. L., & Perdue, M. H. (2000) · Gut · doi:10.1136/gut.47.1.112 · Cited by 277
Tang‐Christensen, M., Larsen, P. J., Thulesen, J., Rømer, J., & Vrang, N. (2000) · Nature Medicine · doi:10.1038/77535 · Cited by 269
Bjerknes, M., & Cheng, H. (1981) · American Journal of Anatomy · doi:10.1002/aja.1001600105 · Cited by 267
Self-citationHousley, R. M., Morris, C. F., Boyle, W., Ring, B. J., Biltz, R., Tarpley, J. E., Aukerman, S. L., Devine, P. L., Whitehead, R., & Pierce, G. F. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117524 · Cited by 266
GLP-2 augments the adaptive response to massive intestinal resection in rat
Scott, R. B., Kirk, D. R., MacNaughton, W. K., & Meddings, J. B. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.5.g911 · Cited by 237
Glucagon-Like Peptide-2 Inhibits Centrally Induced Antral Motility in Pigs
Wøjdemann, M. (1998) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365529850171486 · Cited by 208
Methods for the isolation of intact epithelium from the mouse intestine
Bjerknes, M., & Cheng, H. (1981) · The Anatomical Record · doi:10.1002/ar.1091990412 · Cited by 195
Self-citationWong, W., Poulsom, R., & WRIGHT, N. A. (1999) · Gut · doi:10.1136/gut.44.6.890 · Cited by 184
Deblock, M., & Debrouwer, D. (1993) · Analytical Biochemistry · doi:10.1006/abio.1993.1558 · Cited by 176
Human [Gly2]GLP-2 reduces the severity of colonic injury in a murine model of experimental colitis
Drucker, D. J., Yusta, B., Boushey, R. P., DeForest, L., & Brubaker, P. L. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.276.1.g79 · Cited by 176
Prevention of parenteral nutrition-induced gut hypoplasia by coinfusion of glucagon-like peptide-2
Chance, W. T., Foley‐Nelson, T., Thomas, I., & Balasubramaniam, A. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.273.2.g559 · Cited by 133
Finch, P., Pricolo, V. E., Wu, A., & Finkelstein, S. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8566591 · Cited by 125
Lovshin, J. A., Estall, J. L., Yusta, B., Brown, T. J., & Drucker, D. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009382200 · Cited by 124
Enhancement of Murine Intestinal Stem Cell Survival after Irradiation by Keratinocyte Growth Factor
Khan, W., Shui, C., Ning, S., & Knox, S. J. (1997) · Radiation Research · doi:10.2307/3579609 · Cited by 117
Alavi, K., Schwartz, M. Z., Palazzo, J., & Prasad, R. (2000) · Journal of Pediatric Surgery · doi:10.1053/jpsu.2000.6861 · Cited by 110
Keratinocyte growth factor is highly overexpressed in inflammatory bowel disease.
Brauchle, M. A., Madlener, M., Wagner, A. D., Angermeyer, K., Lauer, U., HOFSCHNEIDER, P. H., Gregor, M., & Werner, S. (1996) · Europe PMC (PubMed Central) · Cited by 109
Glucagon-Like Peptide 2: A Nutrient-Responsive Gut Growth Factor
Burrin, D. G., Stoll, B., Petersen, Y. M., & Sangild, P. T. (2001) · Journal of Nutrition · doi:10.1093/jn/131.3.709 · Cited by 94
Sahara, N., Toyoki, A., Ashizawa, Y., Deguchi, T., & Suzuki, K. T. (1996) · The Anatomical Record · doi:10.1002/(sici)1097-0185(199601)244:1 · Cited by 91
Glucagonoma syndrome demonstrating giant duodenal villi.
Stevens, F. M., Flanagan, R., O’Gorman, D. J., & Buchanan, K. D. (1984) · Gut · doi:10.1136/gut.25.7.784 · Cited by 87
Glucagon-like Peptide 2: A New Treatment for Chemotherapy-Induced Enteritis
Tavakkolizadeh, A., Shen, R., Abraham, P., Kormi, N., Seifert, P. A., Edelman, E. R., Jacobs, D. O., Zinner, M. J., Ashley, S. W., & Whang, E. E. (2000) · Journal of Surgical Research · doi:10.1006/jsre.2000.5917 · Cited by 79
Bajaj‐Elliott, M., Poulsom, R., Pender, S. L. F., Wathen, N. C., & MacDonald, T. T. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2792 · Cited by 78
A new method for the isolation of myenteric plexus from the newborn rat gastrointestinal tract
Schäfer, K., Saffrey, M. J., Burnstock, G., & Mestres-Ventura, P. (1997) · Brain Research Protocols · doi:10.1016/s1385-299x(96)00017-7 · Cited by 75
Chance, W. T., Sheriff, S., Foley‐Nelson, T., Thomas, I., & Balasubramaniam, A. (2000) · Nutrition and Cancer · doi:10.1207/s15327914nc372_15 · Cited by 38
Effects of tetrodotoxin on chloride secretion in rabbit distal colon: tissue and cellular studies
Biagi, B. A., Wang, Y. Z., & Cooke, H. J. (1990) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1990.258.2.g223 · Cited by 27
Chemical modulation of sodium channels
Narahashi, T. (1998) · doi:10.1093/oso/9780198523604.003.0002 · Cited by 8
Research works printed but not linked: 5
- W T Chance, T Foley-Nelson, I Thomas, A Balasubramaniam Am J Physiol 273, G559–G563 (1997).
- M Brauchle, M Madlener, A D Wagner, K Angermeyer, U Lauer, P H Hofschneider, M Gregor, S Werner Am J Pathol 149, 521–529 (1996).
- C L Farrell, J V Bready, K L Rex, J N Chen, C R DiPalma, K L Whitcomb, S Yin, D C Hill, B Wiemann, C O Starnes, et al. Cancer Res 58, 933–939 (1998).
- M Wojdenann, A Wettergren, B Hartmann, J J Holst Scand J Gastroenterol 33, 828–832 (1998).
- B Biagi, Y Z Wang, H J Cooke Am J Physiol 258, G223–G230 (1990).
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Pull, S. L., Doherty, J. M., Mills, J. C., Gordon, J. I., & Stappenbeck, T. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405979102 · Cited by 605
Mitogenic Influence of Human R-Spondin1 on the Intestinal Epithelium
Kim, K., Kakitani, M., Zhao, J., Oshima, T., Tang, T., Binnerts, M. E., Liu, Y., Boyle, B., Park, E., Emtage, P. C. R., et al. (2005) · Science · doi:10.1126/science.1112521 · Cited by 587
Malnutrition as an enteric infectious disease with long-term effects on child development
Guerrant, R. L., Oriá, R. B., Moore, S. R., Oriá, M. O. B., & Lima, A. Â. M. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2008.00082.x · Cited by 556
Brubaker, P. L., & Drucker, D. J. (2004) · Endocrinology · doi:10.1210/en.2004-0015 · Cited by 537
International Union of Pharmacology. XXXV. The Glucagon Receptor Family
Mayo, K. E., Miller, L. J., BATAILLE, D., Dalle, S., Göke, B., Thorens, B., & Drucker, D. J. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.1.6 · Cited by 514
Metadata
- Authors
- Bjerknes, M., & Cheng, H.
- Affiliations
- University of Toronto (CA)
- ORCID
- Bjerknes, Matthew
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2001-09-25
- Volume
- 98
- Issue
- 22
- Pages
- 12497-12502
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC60082
- OpenAlex
- W1987513354
- Cited by
- 325
- References
- 38
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 7 · 2022: 10 · 2021: 7 · 2020: 18 · 2019: 10 · 2018: 14 · 2017: 12 · 2016: 11 · 2015: 9 · 2014: 13 · 2013: 10 · 2012: 13
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Amgen
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
- Keywords
- glucagon-like peptide-2, GLP-2 receptor, enteric neurons, tetrodotoxin, voltage-gated sodium channels, gut-brain signaling
- MeSH terms
- Glucagon-Like Peptide-1 Receptor, Animals, Glucagon-Like Peptides, Intestinal Mucosa, Neurons, Peptides, Stem Cells, Tetrodotoxin, Genes, fos, Receptors, Glucagon, Mice, Glucagon-Like Peptide 2
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