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Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae
Open accessAbstract
In Drosophila , microbial infection activates an antimicrobial defense system involving the activation of proteolytic cascades in the hemolymph and intracellular signaling pathways, the immune deficiency (imd) and Toll pathways, in immune-responsive tissues. The mechanisms for microbial recognition are largely unknown. We report that, in larvae, the imd-mediated antibacterial defense is activated by peptidoglycan-recognition protein (PGRP)-LE, a PGRP-family member in Drosophila . Consistent with this, PGRP-LE binds to the diaminopimelic acid-type peptidoglycan, a cell-wall component of the bacteria capable of activating the imd pathway, but not to the lysine-type peptidoglycan. Moreover, PGRP-LE activates the prophenoloxidase cascade, a proteolytic cascade in the hemolymph. Therefore, PGRP-LE acts as a pattern-recognition receptor to the diaminopimelic acid-type peptidoglycan and activates both the proteolytic cascade and intracellular signaling in Drosophila immunity.
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Citations
Cited by
The Host Defense of Drosophila melanogaster
Lemaitre, B., & Hoffmann, J. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141615 · Cited by 3,324
The immune response of Drosophila
Hoffmann, J. A. (2003) · Nature · doi:10.1038/nature02021 · Cited by 1,553
The proPO-system: pros and cons for its role in invertebrate immunity
Cerenius, L., Lee, B. L., & Söderhäll, K. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.02.009 · Cited by 1,246
Drosophila immunity: paths and patterns
Hultmark, D. (2003) · Current Opinion in Immunology · doi:10.1016/s0952-7915(02)00005-5 · Cited by 600
Kaneko, T., Goldman, W. E., Mellroth, P., Steiner, H., Fukase, K., Kusumoto, S., Harley, W., Fox, A., Golenbock, D., & Silverman, N. (2004) · Immunity · doi:10.1016/s1074-7613(04)00104-9 · Cited by 447
Metadata
- Authors
- Takehana, A., Katsuyama, T., Yano, T., Oshima, Y., Takada, H., Aigaki, T., & Kurata, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-10
- Volume
- 99
- Issue
- 21
- Pages
- 13705-13710
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2152457344
- Cited by
- 350
- References
- 0
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae. https://app.cochat.ai/papers/10.1073/pnas.212301199
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- Takehana, A., Katsuyama, T., Yano, T., Oshima, Y., Takada, H., Aigaki, T., & Kurata, S. (2002). Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.212301199
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