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Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction
Open accessAbstract
Potential repair by cell grafting or mobilizing endogenous cells holds particular attraction in heart disease, where the meager capacity for cardiomyocyte proliferation likely contributes to the irreversibility of heart failure. Whether cardiac progenitors exist in adult myocardium itself is unanswered, as is the question whether undifferentiated cardiac precursor cells merely fuse with preexisting myocytes. Here we report the existence of adult heart-derived cardiac progenitor cells expressing stem cell antigen-1. Initially, the cells express neither cardiac structural genes nor Nkx2.5 but differentiate in vitro in response to 5′-azacytidine, in part depending on Bmpr1a , a receptor for bone morphogenetic proteins. Given intravenously after ischemia/reperfusion, cardiac stem cell antigen 1 cells home to injured myocardium. By using a Cre/Lox donor/recipient pair (α MHC-Cre / R26R ), differentiation was shown to occur roughly equally, with and without fusion to host cells.
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Citations
Cited by
Laflamme, M. A., & Murry, C. E. (2005) · Nature Biotechnology · doi:10.1038/nbt1117 · Cited by 964
Unchain my heart: the scientific foundations of cardiac repair
Dimmeler, S., Zeiher, A. M., & Schneider, M. D. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200524283 · Cited by 668
Self-citationCardiac Myocyte Cell Cycle Control in Development, Disease, and Regeneration
Ahuja, P., Sdek, P., & MacLellan, W. R. (2007) · Physiological Reviews · doi:10.1152/physrev.00032.2006 · Cited by 568
Ellison, G. M., Vicinanza, C., Smith, A. J., Aquila, I., Leone, A., Waring, C. D., Henning, B. J., Stirparo, G. G., Papait, R., Scarfò, M., et al. (2013) · Cell · doi:10.1016/j.cell.2013.07.039 · Cited by 515
Cardiac Stem Cells and Mechanisms of Myocardial Regeneration
Leri, A., Kajstura, J., & Anversa, P. (2005) · Physiological Reviews · doi:10.1152/physrev.00013.2005 · Cited by 451
Metadata
- Authors
- Oh, H., Bradfute, S. B., Gallardo, T. D., Nakamura, T., Gaussin, V., Mishina, Y., Pocius, J., Michael, L. H., Behringer, R. R., Garry, D. J., Entman, M. L., & Schneider, M. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-10-06
- Volume
- 100
- Issue
- 21
- Pages
- 12313-12318
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2122059700
- Cited by
- 1,743
- References
- 0
- FWCI
- 32.81
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction. https://app.cochat.ai/papers/10.1073/pnas.2132126100
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- Oh, H., Bradfute, S. B., Gallardo, T. D., Nakamura, T., Gaussin, V., Mishina, Y., Pocius, J., Michael, L. H., Behringer, R. R., Garry, D. J., Entman, M. L., & Schneider, M. D. (2003). Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2132126100
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