The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1
Open accessAbstract
Patched (Ptc) is the ligand-binding component of the Hedgehog (Hh) receptor complex. In the Drosophila embryo, Ptc and Hh colocalize in vesicular punctate structures. However, receptor-mediated endocytosis of Hh proteins has not been demonstrated. By using chick neural plate explants, we show that Sonic hedgehog (Shh)-responsive neural precursor cells internalize recombinant and endogenous Shh and provide direct evidence for a gradient of endogenous Shh in the ventral neural tube. Shh internalization is blocked by a monoclonal antibody whose epitope overlaps the Ptc-binding site of Shh. These findings suggest that Shh internalization is mediated by Ptc-1 and may be linked to signaling. Concordantly, transfection of mammalian cell lines with a Ptc-1 cDNA confers the ability to internalize multiple forms of Shh, including transmembrane-anchored Shh, by a dynamin-dependent process.
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Citations
Cites
Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants
Goodrich, L. V., Milenković, L., Higgins, K. M., & Scott, M. P. (1997) · Science · doi:10.1126/science.277.5329.1109 · Cited by 1,696
Cited by
Hedgehog: functions and mechanisms
Varjosalo, M., & Taipale, J. (2008) · Genes & Development · doi:10.1101/gad.1693608 · Cited by 1,217
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling
Le Roy, C., & Wrana, J. L. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1571 · Cited by 871
The hedgehog signaling network
Cohen (2003) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.20495 · Cited by 414
Hedgehog–GLI signaling and the growth of the brain
Ruiz i Altaba, A., Palma, V., & Dahmane, N. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn704 · Cited by 376
Capurro, M. I., Xu, P., Shi, W., Li, F., Jia, A., & Filmus, J. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.03.006 · Cited by 364
Metadata
- Authors
- Incardona, J. P., Lee, J. H., Robertson, C. P., Enga, K., Kapur, R. P., & Roelink, H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-10-10
- Volume
- 97
- Issue
- 22
- Pages
- 12044-12049
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1993484166
- Cited by
- 199
- References
- 1
- FWCI
- 5.75
- Type
- journal article
- Language
- en
- Open access
- green
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- Incardona, J. P., Lee, J. H., Robertson, C. P., Enga, K., Kapur, R. P., & Roelink, H. (2000). Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.220251997
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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