Prostate formation in a marsupial is mediated by the testicular androgen 5α-androstane-3α,17β-diol
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Development of the male urogenital tract in mammals is mediated by testicular androgens. It has been tacitly assumed that testosterone acts through its intracellular metabolite dihydrotestosterone (DHT) to mediate this process, but levels of these androgens are not sexually dimorphic in plasma at the time of prostate development. Here we show that the 3 alpha-reduced derivative of DHT, 5 alpha-androstane-3 alpha,17 beta-diol (5 alpha-adiol), is formed in testes of tammar wallaby pouch young and is higher in male than in female plasma in this species during early sexual differentiation. Administration of 5 alpha-adiol caused formation of prostatic buds in female wallaby pouch young, and in tissue minces of urogenital sinus and urogenital tubercle radioactive 5 alpha-adiol was converted to DHT, suggesting that circulating 5 alpha-adiol acts through DHT in target tissues. We conclude that circulating 5 alpha-adiol is a key hormone in male development.
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Normal masculinization of the fetus is dependent upon androgen secretion by the testis, and androgens act initially during a critical masculinization programming window.
“Normal masculinization of the fetus is dependent upon androgen secretion by the testis, and androgens act initially during a critical masculinization programming window to ensure normal male reproductive development [3–5].”
From Alternative (backdoor) androgen production and masculinization in the human fetus (2019) · cites this paper as [3]
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References 32 · Cited by 101
Research works printed but not linked: 1
- [8]Ryhorchuk A R, Shaw G, Butler C M, Renfree M B. J Androl. 1997;181:123–130. [PubMed] [Google Scholar]
- Authors
- Shaw, G., Renfree, M. B., Leihy, M. W., Shackleton, C. H. L., Roitman, E., & Wilson, J. D.
- Affiliations
- Department of Zoology, University of Melbourne, Victoria 3010, Australia; Children's Hospital Oakland Research Institute, 5700 Martin Luther King, Jr. Way, Oakland, CA 94609-1673; and Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8857
- The University of Melbourne (AU)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2000-10-17
- Volume
- 97
- Issue
- 22
- Pages
- 12256-12259
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC17328
- OpenAlex
- W2040536456
- Cited by
- 101
- References
- 32
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2021: 2 · 2020: 2 · 2019: 6 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 3 · 2014: 6 · 2013: 3 · 2012: 3
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- prostate development, 5α-androstane-3α,17β-diol, dihydrotestosterone, testicular androgens, marsupials, tammar wallaby, pouch young, urogenital development, sexual differentiation, urogenital sinus, androgen metabolism
- MeSH terms
- Animals, Female, Macropodidae, Male, Gas Chromatography-Mass Spectrometry, Pregnancy, Prostate, Testis, Androstane-3,17-diol
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