The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Enterocolitis induced by autoimmune targeting of enteric glial cells: A possible mechanism in Crohn's disease?
Open accessAbstract
Early pathological manifestations of Crohn's disease (CD) include vascular disruption, T cell infiltration of nerve plexi, neuronal degeneration, and induction of T helper 1 cytokine responses. This study demonstrates that disruption of the enteric glial cell network in CD patients represents another early pathological feature that may be modeled after CD8+T cell-mediated autoimmune targeting of enteric glia in double transgenic mice. Mice expressing a viral neoself antigen in astrocytes and enteric glia were crossed with specific T cell receptor transgenic mice, resulting in apoptotic depletion of enteric glia to levels comparable in CD patients. Intestinal and mesenteric T cell infiltration, vasculitis, T helper 1 cytokine production, and fulminant bowel inflammation were characteristic hallmarks of disease progression. Immune-mediated damage to enteric glia therefore may participate in the initiation and/or the progression of human inflammatory bowel disease.
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Cites
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Self-citationPATHOGENESIS OF CROHN'S DISEASE: MULTIFOCAL GASTROINTESTINAL INFARCTION
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Cited by
Colonic inflammation in Parkinson's disease
Devos, D., Lebouvier, T., Lardeux, B., Biraud, M., Rouaud, T., Pouclet, H., Coron, E., Bruley des Varannes, S., Naveilhan, P., Nguyen, J.-M., et al. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.09.007 · Cited by 627
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Self-citationNovel functional roles for enteric glia in the gastrointestinal tract
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Ito Cells Are Liver-Resident Antigen-Presenting Cells for Activating T Cell Responses
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Self-citationEnteric glial biology, intercellular signalling and roles in gastrointestinal disease
Seguella, L., & Gulbransen, B. D. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00423-7 · Cited by 323
Metadata
- Authors
- Cornet, A., Savidge, T. C., Cabarrocas, J., Deng, W.-L., Colombel, J.-F., Lassmann, H., Desreumaux, P., & Liblau, R. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-10-30
- Volume
- 98
- Issue
- 23
- Pages
- 13306-13311
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2008752643
- Cited by
- 321
- References
- 45
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Open access
- green
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- Cornet, A., Savidge, T. C., Cabarrocas, J., Deng, W.-L., Colombel, J.-F., Lassmann, H., Desreumaux, P., & Liblau, R. S. (2001). Enterocolitis induced by autoimmune targeting of enteric glial cells: A possible mechanism in Crohn's disease? Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.231474098
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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