The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Regulation of apoptosis at cell division by p34 cdc2 phosphorylation of survivin
Open accessAbstract
The interface between apoptosis (programmed cell death) and the cell cycle is essential to preserve homeostasis and genomic integrity. Here, we show that survivin, an inhibitor of apoptosis over-expressed in cancer, physically associates with the cyclin-dependent kinase p34 cdc2 on the mitotic apparatus, and is phosphorylated on Thr 34 by p34 cdc2 -cyclin B1, in vitro and in vivo . Loss of phosphorylation on Thr 34 resulted in dissociation of a survivin-caspase-9 complex on the mitotic apparatus, and caspase-9-dependent apoptosis of cells traversing mitosis. These data identify survivin as a mitotic substrate of p34 cdc2 -cyclin B1 and suggest that survivin phosphorylation on Thr 34 may be required to preserve cell viability at cell division. Manipulation of this pathway may facilitate the elimination of cancer cells at mitosis.
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Citations
Cites
14-3-3σ is required to prevent mitotic catastrophe after DNA damage
Chan, T. A., Hermeking, H., Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1999) · Nature · doi:10.1038/44188 · Cited by 895
Cited by
Bollrath, J., Phesse, T. J., von Burstin, V. A., Putoczki, T., Bennecke, M., Bateman, T., Nebelsiek, T., Lundgren-May, T., Canli, Ö., Schwitalla, S., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.01.002 · Cited by 946
The inhibitors of apoptosis (IAPs) as cancer targets
Hunter, A. M., LaCasse, E. C., & Korneluk, R. G. (2007) · Apoptosis · doi:10.1007/s10495-007-0087-3 · Cited by 565
Roberson, R. S., Kussick, S. J., Vallieres, E., Chen, S.-Y. J., & Wu, D. Y. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-1270 · Cited by 428
Survivin and IAP proteins in cell-death mechanisms
Altieri, D. C. (2010) · Biochemical Journal · doi:10.1042/bj20100814 · Cited by 376
Self-citationCyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe
Castedo, M., Perfettini, J.-L., Roumier, T., & Kroemer, G. (2002) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401130 · Cited by 345
Metadata
- Authors
- O'Connor, D. S., Grossman, D., Plescia, J., Li, F., Zhang, H., Villa, A., Tognin, S., Marchisio, P. C., & Altieri, D. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-11-07
- Volume
- 97
- Issue
- 24
- Pages
- 13103-13107
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1981006523
- Cited by
- 611
- References
- 1
- FWCI
- 9.46
- Type
- journal article
- Language
- en
- Open access
- green
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- O'Connor, D. S., Grossman, D., Plescia, J., Li, F., Zhang, H., Villa, A., Tognin, S., Marchisio, P. C., & Altieri, D. C. (2000). Regulation of apoptosis at cell division by p34 cdc2 phosphorylation of survivin. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.240390697
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