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Viral protein U counteracts a human host cell restriction that inhibits HIV-1 particle production
Open accessAbstract
Human cells resist viral infections by a variety of mechanisms. Viruses must overcome host cell restrictions to successfully reproduce their genetic material. Here, we identify a host restriction to viral replication that acts at the stage of particle assembly. Viral protein U (Vpu) is an HIV-1 accessory protein that enhances particle assembly and release in most human cells, but not in simian cells. By using human-simian cell heterokaryons, we show that the inhibition of assembly in human cells is dominant. Vpu overcomes the block to assembly in human cells and in human-simian heterokaryons. The HIV-1 vpu gene may have evolved to counteract an assembly restriction that is present in human cells.
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Citations
Cites
Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding
Garrus, J. E., von Schwedler, U. K., Pornillos, O. W., Morham, S. G., Zavitz, K. H., Wang, H. E., Wettstein, D. A., Stray, K. M., Côté, M., Rich, R. L., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00506-2 · Cited by 1,369
Cited by
Van Damme, N., Goff, D., Katsura, C., Jorgenson, R. L., Mitchell, R., Johnson, M. C., Stephens, E. B., & Guatelli, J. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.03.001 · Cited by 1,050
Species-Specific Activity of SIV Nef and HIV-1 Vpu in Overcoming Restriction by Tetherin/BST2
Jia, B., Serra-Moreno, R., Neidermyer, W., Rahmberg, A., Mackey, J., Fofana, I. B., Johnson, W. E., Westmoreland, S., & Evans, D. T. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000429 · Cited by 406
Plasma Membrane Is the Site of Productive HIV-1 Particle Assembly
Jouvenet, N., Neil, S. J. D., Bess, C., Johnson, M. C., Virgen, C. A., Simon, S. M., & Bieniasz, P. D. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040435 · Cited by 357
Rücker, E., Grivel, J.-C., Münch, J., Kirchhoff, F., & Margolis, L. (2004) · Journal of Virology · doi:10.1128/jvi.78.22.12689-12693.2004 · Cited by 48
Metadata
- Authors
- Varthakavi, V., Smith, R. M., Bour, S. P., Strebel, K., & Spearman, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-12
- Volume
- 100
- Issue
- 25
- Pages
- 15154-15159
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2091672669
- Cited by
- 167
- References
- 1
- FWCI
- 3.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Varthakavi, V., Smith, R. M., Bour, S. P., Strebel, K., & Spearman, P. (2003). Viral protein U counteracts a human host cell restriction that inhibits HIV-1 particle production. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2433165100
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