The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
CatSper1 required for evoked Ca 2+ entry and control of flagellar function in sperm
Open accessAbstract
CatSper family proteins are putative ion channels expressed exclusively in membranes of the sperm flagellum and required for male fertility. Here, we show that mouse CatSper1 is essential for depolarization-evoked Ca 2+ entry and for hyperactivated movement, a key flagellar function. CatSper1 is not needed for other developmental landmarks, including regional distributions of Ca V 1.2, Ca V 2.2, and Ca V 2.3 ion channel proteins, the cAMP-mediated activation of motility by \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} \begin{equation*}{\mathrm{HCO}}_{3}^{-}\end{equation*}\end{document} , and the protein phosphorylation cascade of sperm capacitation. We propose that CatSper1 functions as a voltage-gated Ca 2+ channel that controls Ca 2+ entry to mediate the hyperactivated motility needed late in the preparation of sperm for fertilization.
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Cites
Soluble Adenylyl Cyclase as an Evolutionarily Conserved Bicarbonate Sensor
Chen, Y., Cann, M. J., Litvin, T. N., Iourgenko, V., Sinclair, M. L., Levin, L. R., & Buck, J. (2000) · Science · doi:10.1126/science.289.5479.625 · Cited by 846
Cited by
Acid Extrusion from Human Spermatozoa Is Mediated by Flagellar Voltage-Gated Proton Channel
Lishko, P. V., Botchkina, I. L., Fedorenko, A., & Kirichok, Y. (2010) · Cell · doi:10.1016/j.cell.2009.12.053 · Cited by 386
Genetic abnormalities leading to qualitative defects of sperm morphology or function
Ray, P. F., Toure, A., Metzler‐Guillemain, C., Mitchell, M. J., Arnoult, C., & Coutton, C. (2017) · Clinical Genetics · doi:10.1111/cge.12905 · Cited by 179
Jungnickel, M. K., Sutton, K. A., Baker, M. A., Cohen, M. G., Sanderson, M. J., & Florman, H. M. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy105 · Cited by 27
Metadata
- Authors
- Carlson, A. E., Westenbroek, R. E., Quill, T., Ren, D., Clapham, D. E., Hille, B., Garbers, D. L., & Babcock, D. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-12
- Volume
- 100
- Issue
- 25
- Pages
- 14864-14868
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2093444265
- Cited by
- 379
- References
- 1
- FWCI
- 13.13
- Type
- journal article
- Language
- en
- Open access
- green
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- Carlson, A. E., Westenbroek, R. E., Quill, T., Ren, D., Clapham, D. E., Hille, B., Garbers, D. L., & Babcock, D. F. (2003). CatSper1 required for evoked Ca 2+ entry and control of flagellar function in sperm. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2536658100
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