Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence

The proliferation of most primary cells in culture is limited by replicative senescence and crisis, p53-dependent events. However, the regulation of p53 itself has not been defined. We find that deletion of the early growth response 1 (EGR1) transcription factor leads to a striking phenotype, inc…