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AN ESTIMATE OF THE MUTATIONAL DAMAGE IN MAN FROM DATA ON CONSANGUINEOUS MARRIAGES
Open accessAbstract
6 Here and later we are making the simplifying assumption that a pre-existing mutant allele has the same effect on viability as the new mutant.This is justified as a first approximation by the observation that compounds of mutants are often near the average of the mutant homozygotes.'his formula is given for only two alleles, but the extension to a larger number is obvious and the linearity in F remains.In applying this to a real population, we assume F = 0 for all individuals not known to come from a consanguineous marriage.
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Citations
Cited by
Identification of deleterious mutations within three human genomes
Chun, S., & Fay, J. C. (2009) · Genome Research · doi:10.1101/gr.092619.109 · Cited by 1,049
Mutation Accumulation and the Extinction of Small Populations
Lynch, M., Conery, J., & Burger, R. (1995) · The American Naturalist · doi:10.1086/285812 · Cited by 1,049
Understanding Inbreeding Depression, Purging, and Genetic Rescue
Hedrick, P. W., & Garcia-Dorado, A. (2016) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2016.09.005 · Cited by 668
Inbreeding and Extinction: A Threshold Effect
Frankham, R. (1995) · Conservation Biology · doi:10.1046/j.1523-1739.1995.09040792.x · Cited by 601
Realistic levels of inbreeding depression strongly affect extinction risk in wild populations
O’Grady, J. J., Brook, B. W., Reed, D. H., Ballou, J. D., Tonkyn, D. W., & Frankham, R. (2006) · Biological Conservation · doi:10.1016/j.biocon.2006.05.016 · Cited by 498
Metadata
- Authors
- Morton, N. E., Crow, J. F., & Muller, H. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1956-11
- Volume
- 42
- Issue
- 11
- Pages
- 855-863
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2040560871
- Cited by
- 789
- References
- 0
- FWCI
- 12.11
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: AN ESTIMATE OF THE MUTATIONAL DAMAGE IN MAN FROM DATA ON CONSANGUINEOUS MARRIAGES. https://app.cochat.ai/papers/10.1073/pnas.42.11.855
- The paper
- Morton, N. E., Crow, J. F., & Muller, H. J. (1956). AN ESTIMATE OF THE MUTATIONAL DAMAGE IN MAN FROM DATA ON CONSANGUINEOUS MARRIAGES. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.42.11.855
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
