The DOI matches its Crossref record.
α-KETO ACID DEHYDROGENASE COMPLEXES, XI. COMPARATIVE STUDIES OF REGULATORY PROPERTIES OF THE PYRUVATE DEHYDROGENASE COMPLEXES FROM KIDNEY, HEART, AND LIVER MITOCHONDRIA
Open accessAbstract
The activity of the multienzyme pyruvate dehydrogenase complexes, isolated from mitochondria of beef kidney, beef heart, and pork liver, is regulated by phosphorylation and dephosphorylation. Phosphorylation and concomitant inactivation of each of the three complexes are catalyzed by an ATP-specific kinase, and dephosphorylation and concomitant reactivation are catalyzed by a phosphatase. The phosphatase has been separated from the other component enzymes of each pyruvate dehydrogenase complex, and the three phosphatases are functionally interchangeable. The kinase has been isolated from the beef kidney complex, and it is functional with the beef heart and pork liver complexes. ADP is competitive with ATP, and the ADP effect is more pronounced with the kidney kinase than with the liver and heart kinases. Pyruvate protects strongly the heart and liver pruvate dehydrogenase complexes and, to a lesser extent, the kidney complex against inactivation by ATP. Pyruvate apparently exerts its effect on the pyruvate dehydrogenase component of the complex, rather than on the kinase.
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Cited by
The Metabolism of Rat Brain Mitochondria
Clark, J. B., & Nicklas, W. J. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62854-6 · Cited by 559
On the role of the calcium transport cycle in heart and other mammalian mitochondria
Denton, R. M., & McCormack, J. G. (1980) · FEBS Letters · doi:10.1016/0014-5793(80)80986-0 · Cited by 388
Scholz, R., Hansen, W., & Thurman, R. G. (1973) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1973.tb03034.x · Cited by 302
Wieland, O. H., Patzelt, C., & Löffler, G. (1972) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1972.tb01783.x · Cited by 198
Rate control of the tricarboxylic acid cycle
Krebs, H. A. (1970) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(70)90028-2 · Cited by 196
Metadata
- Authors
- Linn, T. C., Pettit, F. H., Hucho, F., & Reed, L. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1969-09
- Volume
- 64
- Issue
- 1
- Pages
- 227-234
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2042478578
- Cited by
- 352
- References
- 0
- FWCI
- 7.05
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: α-KETO ACID DEHYDROGENASE COMPLEXES, XI. COMPARATIVE STUDIES OF REGULATORY PROPERTIES OF THE PYRUVATE DEHYDROGENASE COMPLEXES FROM KIDNEY, HEART, AND LIVER MITOCHONDRIA. https://app.cochat.ai/papers/10.1073/pnas.64.1.227
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- Linn, T. C., Pettit, F. H., Hucho, F., & Reed, L. J. (1969). α-KETO ACID DEHYDROGENASE COMPLEXES, XI. COMPARATIVE STUDIES OF REGULATORY PROPERTIES OF THE PYRUVATE DEHYDROGENASE COMPLEXES FROM KIDNEY, HEART, AND LIVER MITOCHONDRIA. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.64.1.227
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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