The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Specific Nucleolar and Nucleoplasmic RNA Polymerases
Open accessAbstract
The DNA-dependent RNA polymerase activity present in rat liver nuclei has been solubilized and purified from whole nuclei and from subnuclear fractions. As reported earlier (Roeder, R. G., and W. J. Rutter, Nature , 224, 234 (1969)), two major chromatographically distinct enzymatic species (I and II) are present in whole nuclei. Subfractionation of whole nuclei into nucleolar and nucleoplasmic fractions had little effect on the total recovery of activity. Purified nucleoli contain predominantly polymerase I, whereas the nucleoplasmic fraction is greatly enriched for polymerase II. A third minor peak of activity has also been resolved in the nucleoplasmic preparations. We conclude that the RNA polymerases are specifically localized within the nucleus and may, therefore, play specific roles in the regulation of genetic transcription.
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Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 317,331
Burton, K. (1956) · Biochemical Journal · doi:10.1042/bj0620315 · Cited by 14,090
Nuclei from Rat Liver: Isolation Method That Combines Purity with High Yield
Blobel, G., & Potter, V. R. (1966) · Science · doi:10.1126/science.154.3757.1662 · Cited by 1,667
Multiple Forms of DNA-dependent RNA Polymerase in Eukaryotic Organisms
ROEDER, R. G., & RUTTER, W. J. (1969) · Nature · doi:10.1038/224234a0 · Cited by 970
Self-citationDEOXYRIBONUCLEIC ACID-DIRECTED SYNTHESIS OF RIBONUCLEIC ACID BY AN ENZYME FROM ESCHERICHIA COLI
Chamberlin, M., & Berg, P. (1962) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.48.1.81 · Cited by 627
Hormones and the Synthesis and Utilization of Ribonucleic Acids
Tata, J. R. (1966) · Progress in Nucleic Acid Research and Molecular Biology · doi:10.1016/s0079-6603(08)60235-4 · Cited by 197
THE RELATIONSHIP OF THE NUCLEOLUS TO THE SYNTHESIS OF RIBOSOMAL RNA IN HELA CELLS
McConkey, E. H., & Hopkins, J. W. (1964) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.51.6.1197 · Cited by 155
Cited by
MYC as a regulator of ribosome biogenesis and protein synthesis
van Riggelen, J., Yetil, A., & Felsher, D. W. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2819 · Cited by 956
Metadata
- Authors
- Roeder, R. G., & Rutter, W. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1970-03
- Volume
- 65
- Issue
- 3
- Pages
- 675-682
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2084145961
- Cited by
- 455
- References
- 7
- FWCI
- 32.64
- Type
- journal article
- Language
- en
- Open access
- green
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