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Elevation of Guanosine 3′,5′-Cyclic Phosphate in Rat Heart after Perfusion with Acetylcholine
Open accessAbstract
The levels of guanosine 3′,5′-cyclic phosphate (cGMP) and adenosine 3′,5′-cyclic phosphate (cAMP) were measured in rat hearts after perfusion with acetylcholine to determine if parallel or independent changes occurred in the levels of these two cyclic nucleotides. It was found that after perfusion with the cholinergic agent tissue, cGMP levels increased as much as 140%. This was accompanied by no change or slight decreases in cardiac cAMP concentrations. The increases observed in cGMP levels were found to parallel the negative inotropic but not the negative chronotropic effects of acetylcholine. Perfusion with isoproterenol led to increases in the rate and force of cardiac contractility and a lowering of cGMP levels. It was concluded that the tissue concentrations of cGMP and cAMP in the perfused rat heart can vary independently and that these two tissue cyclic nucleotides probably do not share the same metabolic or functional role in this tissue.
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Citations
Cited by
Greengard, P. (1978) · Science · doi:10.1126/science.22932 · Cited by 965
8-bromo-cGMP reduces the myofilament response to Ca2+ in intact cardiac myocytes.
Shah, A. M., Spurgeon, H. A., Sollott, S. J., Talo, A., & Lakatta, E. G. (1994) · Circulation Research · doi:10.1161/01.res.74.5.970 · Cited by 377
A Short History of cGMP, Guanylyl Cyclases, and cGMP-Dependent Protein Kinases
Kots, A. Y., Martin, E., Sharina, I. G., & Murad, F. (2009) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-540-68964-5_1 · Cited by 82
Effect of lithium on the physostigmine-induced behavioral syndrome and plasma cyclic GMP
Oppenheim, G., Ebstein, R. P., & Belmaker, R. H. (1979) · Journal of Psychiatric Research · doi:10.1016/0022-3956(79)90024-4 · Cited by 48
Metadata
- Authors
- George, W. J., Polson, J. B., O'Toole, A. G., & Goldberg, N. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1970-06
- Volume
- 66
- Issue
- 2
- Pages
- 398-403
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2028285911
- Cited by
- 452
- References
- 0
- FWCI
- 11.72
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Elevation of Guanosine 3′,5′-Cyclic Phosphate in Rat Heart after Perfusion with Acetylcholine. https://app.cochat.ai/papers/10.1073/pnas.66.2.398
- The paper
- George, W. J., Polson, J. B., O'Toole, A. G., & Goldberg, N. D. (1970). Elevation of Guanosine 3′,5′-Cyclic Phosphate in Rat Heart after Perfusion with Acetylcholine. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.66.2.398
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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