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Hemoglobin Synthesis in Murine Virus-Induced Leukemic Cells In Vitro: Stimulation of Erythroid Differentiation by Dimethyl Sulfoxide
Open accessAbstract
Cells of a cloned line of murine virus-induced erythroleukemia were stimulated to differentiate along the erythroid pathway by dimethyl sulfoxide at concentrations that did not inhibit growth. A rise in the number of benzidine-positive normoblasts was accompanied by increased synthesis of heme and hemoglobin and a decrease in the malignancy of the cells. This action of dimethyl sulfoxide, which was reversible, may represent the derepression of leukemic cells to permit their maturation.
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Citations
Cited by
Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid
Breitman, T. R., Selonick, S. E., & Collins, S. J. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.5.2936 · Cited by 1,966
Histone deacetylases and cancer: causes and therapies
Marks, P. A., Rifkind, R. A., Richon, V. M., Breslow, R., Miller, T., & Kelly, W. K. (2001) · Nature reviews. Cancer · doi:10.1038/35106079 · Cited by 1,866
Phenotypic screening in cancer drug discovery — past, present and future
Moffat, J. G., Rudolph, J., & Bailey, D. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4366 · Cited by 507
Coppola, J. A., & Cole, M. D. (1986) · Nature · doi:10.1038/320760a0 · Cited by 503
Induction of erythroid differentiation in the human leukaemia cell line K562
ANDERSSON, L. C., JOKINEN, M., & GAHMBERG, C. G. (1979) · Nature · doi:10.1038/278364a0 · Cited by 466
Metadata
- Authors
- Friend, C., Scher, W., Holland, J. G., & Sato, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1971-02
- Volume
- 68
- Issue
- 2
- Pages
- 378-382
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1979704489
- Cited by
- 1,352
- References
- 0
- FWCI
- 19.79
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Hemoglobin Synthesis in Murine Virus-Induced Leukemic Cells In Vitro: Stimulation of Erythroid Differentiation by Dimethyl Sulfoxide. https://app.cochat.ai/papers/10.1073/pnas.68.2.378
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- Friend, C., Scher, W., Holland, J. G., & Sato, T. (1971). Hemoglobin Synthesis in Murine Virus-Induced Leukemic Cells In Vitro: Stimulation of Erythroid Differentiation by Dimethyl Sulfoxide. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.68.2.378
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
