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An Enzyme-Based Theory of Obligate Anaerobiosis: The Physiological Function of Superoxide Dismutase
Open accessAbstract
The distribution of catalase and superoxide dismutase has been examined in various micro-organisms. Strict anaerobes exhibited no superoxide dismutase and, generally, no catalase activity. All aerobic organisms containing cytochrome systems were found to contain both superoxide dismutase and catalase. Aerotolerant anaerobes, which survive exposure to air and metabolize oxygen to a limited extent but do not contain cytochrome systems, were found to be devoid of catalase activity but did exhibit superoxide dismutase activity. This distribution is consistent with the proposal that the prime physiological function of superoxide dismutase is protection of oxygen-metabolizing organisms against the potentially detrimental effects of the superoxide free radical, a biologically produced intermediate resulting from the univalent reduction of molecular oxygen.
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Citations
Cited by
Superoxide radical and superoxide dismutases
Fridovich, I. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.000525 · Cited by 3,455
Self-citationFridovich (1978) · doi:10.1126/science.210504 · Cited by 3,329
Cellular Defenses against Superoxide and Hydrogen Peroxide
Imlay, J. A. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061606.161055 · Cited by 1,563
A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding
Perron, N. R., & Brumaghim, J. L. (2009) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-009-9043-x · Cited by 1,370
Fridovich, I. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83102-7 · Cited by 964
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Metadata
- Authors
- McCord, J. M., Keele, B. B., & Fridovich, I.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1971-05
- Volume
- 68
- Issue
- 5
- Pages
- 1024-1027
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2157358457
- Cited by
- 973
- References
- 0
- FWCI
- 11.00
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: An Enzyme-Based Theory of Obligate Anaerobiosis: The Physiological Function of Superoxide Dismutase. https://app.cochat.ai/papers/10.1073/pnas.68.5.1024
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- McCord, J. M., Keele, B. B., & Fridovich, I. (1971). An Enzyme-Based Theory of Obligate Anaerobiosis: The Physiological Function of Superoxide Dismutase. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.68.5.1024
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