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Specific Cytoplasmic Glucocorticoid Hormone Receptors in Hepatoma Tissue Culture Cells
Open accessAbstract
Kinetic and equilibrium studies are presented for the reversible binding of [ 3 H]dexamethasone by “specific” macromolecular receptors in the cytoplasmic fraction of cultured rat hepatoma cells. As in the case of the nuclear receptors in the same cells, the binding affinities of various steroids for the cytoplasmic receptors are closely correlated with the activities of these compounds as inducers of both tyrosine aminotransferase (EC 2.6.1.5) and cell adhesiveness. This suggests that the binding reaction is important for the biological effects of the hormones. Steroid-binding activity is inhibited by various proteases, mercurials, and 1 M KCl, but not by DNase or RNase. The receptors sediment in sucrose gradients in 0.5 M KCl near 4S, and at lower ionic strength near 7S; some of their physical properties are altered upon binding steroid. Bound dexamethasone can be recovered from the receptors as the unaltered steroid.
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Citations
Cited by
Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones*
Pratt, W. B., & Toft, D. O. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.3.0303 · Cited by 1,791
Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids
Blackwell, G. J., Carnuccio, R., Rosa, M. D., Flower, R. J., Parente, L., & Persico, P. (1980) · Nature · doi:10.1038/287147a0 · Cited by 915
Baulieu, E.-E., Atger, M., Best-Belpomme, M., Corvol, P., Courvalin, J.-C., Mester, J., Milgrom, E., Robel, P., Rochefort, H., & Catalogne, D. D. (1976) · Vitamins & Hormones · doi:10.1016/s0083-6729(08)60974-7 · Cited by 341
Freeman, B. C., Felts, S. J., Toft, D. O., & Yamamoto, K. R. (2000) · Genes & Development · doi:10.1101/gad.14.4.422 · Cited by 168
Molitoris, J. K., McColl, K. S., Swerdlow, S., Matsuyama, M., Lam, M., Finkel, T. H., Matsuyama, S., & Distelhorst, C. W. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.245423 · Cited by 96
Metadata
- Authors
- Baxter, J. D., & Tomkins, G. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1971-05
- Volume
- 68
- Issue
- 5
- Pages
- 932-937
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2090691291
- Cited by
- 330
- References
- 0
- FWCI
- 22.86
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Specific Cytoplasmic Glucocorticoid Hormone Receptors in Hepatoma Tissue Culture Cells. https://app.cochat.ai/papers/10.1073/pnas.68.5.932
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- Baxter, J. D., & Tomkins, G. M. (1971). Specific Cytoplasmic Glucocorticoid Hormone Receptors in Hepatoma Tissue Culture Cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.68.5.932
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
