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Selective Induction by Nerve Growth Factor of Tyrosine Hydroxylase and Dopamine-β-Hydroxylase in the Rat Superior Cervical Ganglia
Open accessAbstract
Treatment of newborn rats with 10 μg/g of nerve growth factor for 10 days enhanced not only the growth but also the differentiation of neuroblasts in superior cervical ganglia. These morphological changes were accompanied by selective induction of tyrosine hydroxylase and dopamine β-hydroxylase (EC 1.14.2.1), whereas the total and specific activities of other enzymes involved in biosynthesis or metabolic degradation of norepinephrine rose only in proportion to the increase in volume of the sympathetic ganglia. There are remarkable similarities between this effect of nerve growth factor and the induction of trans-synaptic enzymes by increased activity of the sympathetic nervous system.
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Citations
Cited by
The Nerve Growth Factor 35 Years Later
Levi-Montalcini, R. (1987) · Science · doi:10.1126/science.3306916 · Cited by 3,125
Self-citationExpression and structure of the human NGF receptor
Johnson, D., Lanahan, A., Buck, C. R., Sehgal, A., Morgan, C., Mercer, E., Bothwell, M., & Chao, M. (1986) · Cell · doi:10.1016/0092-8674(86)90619-7 · Cited by 963
The nerve growth factor: thirty-five years later.
Levi-Montalcini, R. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02347.x · Cited by 718
Self-citationPatterson, S. L., Grover, L. M., Schwartzkroin, P. A., & Bothwell, M. (1992) · Neuron · doi:10.1016/0896-6273(92)90067-n · Cited by 555
Review lecture. Neurotransmitters and trophic factors in the autonomic nervous system.
Burnstock, G. (1981) · The Journal of Physiology · doi:10.1113/jphysiol.1981.sp013648 · Cited by 373
Metadata
- Authors
- Thoenen, H., Angeletti, P. U., Levi-Montalcini, R., & Kettler, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1971-07
- Volume
- 68
- Issue
- 7
- Pages
- 1598-1602
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2076876783
- Cited by
- 312
- References
- 0
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Selective Induction by Nerve Growth Factor of Tyrosine Hydroxylase and Dopamine-β-Hydroxylase in the Rat Superior Cervical Ganglia. https://app.cochat.ai/papers/10.1073/pnas.68.7.1598
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- Thoenen, H., Angeletti, P. U., Levi-Montalcini, R., & Kettler, R. (1971). Selective Induction by Nerve Growth Factor of Tyrosine Hydroxylase and Dopamine-β-Hydroxylase in the Rat Superior Cervical Ganglia. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.68.7.1598
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
