Potassium: Effect on DNA Synthesis and Multiplication of Baby-Hamster Kidney Cells
Open accessAbstract
The relations between DNA synthesis, cell multiplication, and external potassium concentration have been investigated in cultured baby-hamster kidney cells. When the potassium concentration was raised from 8 mM to 114 mM by equimolar replacement of sodium, DNA synthesis and cell multiplication were almost completely inhibited. This inhibition was reversible even after 72 hr of incubation in medium with a high concentration of potassium. There is a consistent difference between the cultured cells and polyoma virus-transformed cells in response to high-potassium medium, a higher-potassium concentration being required to inhibit multiplication of polyoma virus-transformed cells to the same extent as that of the nontransformed cells.
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In both highly proliferative tumor and non-tumor cells, depolarization is believed to serve as a signal that could initiate mitosis and DNA synthesis.
“In general, in both highly proliferative tumor and non-tumor cells, depolarization is believed to serve as a signal that could initiate mitosis and DNA synthesis (Orr et al., 1972; Binggeli and Weinstein, 1986).”
From Membrane potential and cancer progression (2013) · cites this paper as Orr et al., 1972
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Membrane potential and cancer progression
Yang, M., & Brackenbury, W. J. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00185 · Cited by 614 · see citing works
Bioelectric controls of cell proliferation: Ion channels, membrane voltage and the cell cycle
Blackiston, D. J., McLaughlin, K. A., & Levin, M. (2009) · Cell Cycle · doi:10.4161/cc.8.21.9888 · Cited by 468 · see citing works
- Authors
- Orr, C. W., Yoshikawa-Fukada, M., & Ebert, J. D.
- Affiliations
- Carnegie Institution for Science (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1972-01
- Volume
- 69
- Issue
- 1
- Pages
- 243-247
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC427584
- OpenAlex
- W2125862292
- Cited by
- 72
- References
- 0
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2013: 1
- FWCI
- 5.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- potassium, DNA synthesis, cell proliferation, BHK cells, sodium substitution, cell transformation, reversible inhibition
- MeSH terms
- Animals, Cell Division, Cell Line, Cell Transformation, Neoplastic, Cells, Cultured, Culture Media, Depression, Chemical, DNA, DNA Replication, Cricetinae, Kidney, Microscopy, Phase-Contrast, Osmolar Concentration, Polyomavirus, Potassium, RNA
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