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Primary Structure of the Ovine Hypothalamic Luteinizing Hormone-Releasing Factor (LRF)
Open accessAbstract
The primary structure of ovine hypothalamic hypophysiotropic luteinizing hormone-releasing factor, LRF, has been established as pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH 2 by hydrolysis of the peptide with chymotrypsin or pyrrolidone-carboxylylpeptidase and by analysis of the products by an Edman-dansylation sequencing technique, as well as by mass spectrometry of the derived phenylthiohydantoins. A decapeptide with the proposed primary structure, prepared by total synthesis, gave the same result on sequencing. The synthetic decapeptide possesses the same biological activities as the native ovine LRF. The amino-acid sequence of ovine LRF is identical to that already published for porcine LRF.
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Citations
Cited by
Oyola, M. G., & Handa, R. J. (2017) · Stress · doi:10.1080/10253890.2017.1369523 · Cited by 710
“GnRH, independently discovered by Andrew Schally and Roger Guillemin and coworkers over 45 years ago (Burgus et al., 1972; Schally, Nair, Redding, & Arimura, 1971), is synthesized and secreted from a subset of neurons in the rostral forebrain of rodents (Jennes & Conn, 1994).”
BackgroundCharacterization of a teleost gonadotropin-releasing hormone.
Sherwood, N., Eiden, L., Brownstein, M., Spiess, J., Rivier, J., & Vale, W. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.9.2794 · Cited by 349
Self-citationPrimary structure of gonadotropin-releasing hormone from lamprey brain.
Sherwood, N. M., Sower, S. A., Marshak, D. R., Fraser, B. A., & Brownstein, M. J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)89177-9 · Cited by 253
Estradiol Down-Regulates RF-Amide-Related Peptide (RFRP) Expression in the Mouse Hypothalamus
Molnár, C. S., Kalló, I., Liposits, Z., & Hrabovszky, E. (2011) · Endocrinology · doi:10.1210/en.2010-1418 · Cited by 80
Induction of gamete release by gonadotropin-releasing hormone in a protochordate, Ciona intestinalis
Terakado, K. (2001) · General and Comparative Endocrinology · doi:10.1006/gcen.2001.7728 · Cited by 80
Metadata
- Authors
- Burgus, R., Butcher, M., Amoss, M., Ling, N., Monahan, M., Rivier, J., Fellows, R., Blackwell, R., Vale, W., & Guillemin, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1972-01
- Volume
- 69
- Issue
- 1
- Pages
- 278-282
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2003845868
- Cited by
- 476
- References
- 0
- FWCI
- 13.91
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Burgus, R., Butcher, M., Amoss, M., Ling, N., Monahan, M., Rivier, J., Fellows, R., Blackwell, R., Vale, W., & Guillemin, R. (1972). Primary Structure of the Ovine Hypothalamic Luteinizing Hormone-Releasing Factor (LRF). Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.69.1.278
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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