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Biochemical Sequences in the Transformation of Normal Fibroblasts in Adolescent Rats
Open accessAbstract
Coarse powders of acid-insoluble matrix of diaphysis and calvarial parietal bone rapidly and consistently transformed fibroblasts into masses of cartilage and bone containing hemopoietic marrow. The transformant was encapsulated by fibroblasts within 24 hr to form a plaque. Transformation was restricted to the central thicknesses of the plaque. Under the stated conditions the alteration of the phenotype, fibroblast to chondroblast, was an unstable transformation, whereas the phenotype change, fibroblast to osteoblast, was stable. The transformation occurred on a rigid timetable of sequences. Measurements of alkaline phosphatase activity and incorporation of radioactive sulfate, phosphate, and calcium were sensitive and quantitative assays for the appearance of the transformed products, cartilage and bone.
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Winkler, T., Sass, F. A., Duda, G. N., & Schmidt-Bleek, K. (2018) · Bone & Joint Research · doi:10.1302/2046-3758.73.bjr-2017-0270.r1 · Cited by 482
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Metadata
- Authors
- Reddi, A. H., & Huggins, C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1972-06
- Volume
- 69
- Issue
- 6
- Pages
- 1601-1605
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2156204832
- Cited by
- 810
- References
- 0
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Biochemical Sequences in the Transformation of Normal Fibroblasts in Adolescent Rats. https://app.cochat.ai/papers/10.1073/pnas.69.6.1601
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- Reddi, A. H., & Huggins, C. (1972). Biochemical Sequences in the Transformation of Normal Fibroblasts in Adolescent Rats. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.69.6.1601
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
