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β 2 -Microglobulin—A Free Immunoglobulin Domain
Open accessAbstract
Analysis of the primary structure of β 2 -microglobulin indicates that this human protein is homologous in sequence to the constant portion of immunoglobulin light chains (C L ), and to the homology regions (C H 1, C H 2, and C H 3) of the constant portion of γ1 (heavy) chains of immunoglobulin G. Homology with the C H 3 region is particularly striking. No convincing homology could be demonstrated by similar comparisons with the variable regions of immunoglobulin light and heavy chains. β 2 -Microglobulin contains an intrachain disulfide loop of 57 amino-acid residues that is similar in size to disulfide loops found in the constant regions of immunoglobulin G. These findings suggest that β 2 -microglobulin is a free immunoglobulin domain, possibly serving an effector function similar to that of the C H 3 domain of γ1 chains of immunoglobulin G.
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Cited by
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Eigel, W. N., Butler, J. E., Ernstrom, C. A., Farrell, H. M., Harwalkar, V. R., Jenness, R., & Whitney, R. M. (1984) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(84)81485-x · Cited by 872
Neuronal Cell Thy-1 Glycoprotein: Homology with Immunoglobulin
Williams, A. F., & Gagnon, J. (1982) · Science · doi:10.1126/science.6177036 · Cited by 517
Metadata
- Authors
- Peterson, P. A., Cunningham, B. A., Berggård, I., & Edelman, G. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1972-07
- Volume
- 69
- Issue
- 7
- Pages
- 1697-1701
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2081018997
- Cited by
- 387
- References
- 0
- FWCI
- 46.30
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: β 2 -Microglobulin—A Free Immunoglobulin Domain. https://app.cochat.ai/papers/10.1073/pnas.69.7.1697
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- Peterson, P. A., Cunningham, B. A., Berggård, I., & Edelman, G. M. (1972). β 2 -Microglobulin—A Free Immunoglobulin Domain. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.69.7.1697
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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