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Purification and Biological Activity of Thymosin, a Hormone of the Thymus Gland
Open accessAbstract
The purification and chemical properties of thymosin, obtained from bovine thymus tissue, are described. The biological activity of the thymic hormone has been assessed by a newly developed rosette assay, which permits measurement of thymus-dependent lymphoid cells. Thymosin activity is associated with a physico-chemically homogeneous protein of molecular weight 12,600. The hormonal activity is evident in in vitro incubation assay, after injection into adult thymectomized mice, and in prolonging survival of neonatally thymectomized mice and the reconstitution of their response to a skin allograft.
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Cited by
Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide.
Goldstein, A. L., Low, T. L., McAdoo, M., McClure, J., Thurman, G. B., Rossio, J., Lai, C. Y., Chang, D., Wang, S. S., Harvey, C., et al. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.2.725 · Cited by 355
Self-citationT cell regeneration after immunological injury
Velardi, E., Tsai, J. J., & van den Brink, M. R. M. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00457-z · Cited by 222
Metadata
- Authors
- Goldstein, A. L., Guha, A., Zatz, M. M., Hardy, M. A., & White, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1972-07
- Volume
- 69
- Issue
- 7
- Pages
- 1800-1803
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2164653792
- Cited by
- 306
- References
- 0
- FWCI
- 8.89
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Purification and Biological Activity of Thymosin, a Hormone of the Thymus Gland. https://app.cochat.ai/papers/10.1073/pnas.69.7.1800
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- Goldstein, A. L., Guha, A., Zatz, M. M., Hardy, M. A., & White, A. (1972). Purification and Biological Activity of Thymosin, a Hormone of the Thymus Gland. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.69.7.1800
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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