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Nonchromosomal Antibiotic Resistance in Bacteria: Genetic Transformation of Escherichia coli by R-Factor DNA
Open accessAbstract
Transformation of E. coli cells treated with CaCl 2 to multiple antibiotic resistance by purified R-factor DNA is reported. Drug resistance is expressed in a small fraction of the recipient bacterial population almost immediately after uptake of DNA, but full genetic expression of resistance requires subsequent incubation in drugfree medium before antibiotic challenge. Transformed bacteria acquire a closed circular, transferable DNA species having the resistance, fertility, and sedimentation characteristics of the parent R factor. Covalently-closed, catenated, and open (nicked) circular forms of R-factor DNA are all effective in transformation, but denaturation and sonication abolish the transforming ability of R-factor DNA in this system.
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Citations
Cited by
Molecular Basis of Bacterial Outer Membrane Permeability Revisited
Nikaido, H. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.4.593-656.2003 · Cited by 4,316
Yeast/E. coli shuttle vectors with multiple unique restriction sites
Hill, J. E., Myers, A. M., Koerner, T. J., & Tzagoloff, A. (1986) · Yeast · doi:10.1002/yea.320020304 · Cited by 1,382
Hood, E. E., Helmer, G. L., Fraley, R. T., & Chilton, M. D. (1986) · Journal of Bacteriology · doi:10.1128/jb.168.3.1291-1301.1986 · Cited by 873
The transition state transcription regulator abrB of Bacillus subtilis is a DNA binding protein.
Strauch, M. A., Spiegelman, G. B., Perego, M., Johnson, W. C., Burbulys, D., & Hoch, J. A. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03546.x · Cited by 271
Gómez-Duarte, O. G., & Kaper, J. B. (1995) · Infection and Immunity · doi:10.1128/iai.63.5.1767-1776.1995 · Cited by 265
Metadata
- Authors
- Cohen, S. N., Chang, A. C. Y., & Hsu, L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1972-08
- Volume
- 69
- Issue
- 8
- Pages
- 2110-2114
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2014117083
- Cited by
- 2,699
- References
- 0
- FWCI
- 15.17
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Nonchromosomal Antibiotic Resistance in Bacteria: Genetic Transformation of Escherichia coli by R-Factor DNA. https://app.cochat.ai/papers/10.1073/pnas.69.8.2110
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- Cohen, S. N., Chang, A. C. Y., & Hsu, L. (1972). Nonchromosomal Antibiotic Resistance in Bacteria: Genetic Transformation of Escherichia coli by R-Factor DNA. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.69.8.2110
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
