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Synaptic Rearrangement in the Dentate Gyrus: Histochemical Evidence of Adjustments after Lesions in Immature and Adult Rats
Open accessAbstract
In immature animals, ablation of the entorhinal cortex elicited a rapid intensification of acetylcholinesterase (EC 3.1.1.7) staining in the outer one-quarter of the molecular layer of the dentate gyrus. Subsequent lesions of the septum eliminated this acetylcholinesterase intensification. Electron-microscopic histochemical analysis demonstrated a 30-fold increase in the number of acetylcholinesterase-positive synaptic endings in the intensification zone. The acetylcholinesterase augmentation thus appears attributable, in part at least, to an increase in the number of acetylcholinesterase-rich synaptic endings established by septo-hippocampal fibers. Observations in a comparative study of immature and adult rats point to the animal's developmental state as a major determinant of differences in these lesion-induced neuronal adjustments.
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Citations
Cited by
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Lamprecht, R., & LeDoux, J. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1301 · Cited by 1,010
DeKosky, S. T., Ikonomovic, M. D., Styren, S. D., Beckett, L., Wisniewski, S., Bennett, D. A., Cochran, E. J., Kordower, J. H., & Mufson, E. J. (2002) · Annals of Neurology · doi:10.1002/ana.10069 · Cited by 686
A review of adversity, the amygdala and the hippocampus: a consideration of developmental timing
Tottenham, N. (2009) · Frontiers in Human Neuroscience · doi:10.3389/neuro.09.068.2009 · Cited by 651
Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications
Mufson, E. J., Counts, S. E., Perez, S. E., & Ginsberg, S. D. (2008) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.8.11.1703 · Cited by 587
Matthews, D. A., Cotman, C., & Lynch, G. (1976) · Brain Research · doi:10.1016/0006-8993(76)90820-9 · Cited by 384
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Metadata
- Authors
- Cotman, C. W., Matthews, D. A., Taylor, D., & Lynch, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1973-12
- Volume
- 70
- Issue
- 12
- Pages
- 3473-3477
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2006411038
- Cited by
- 191
- References
- 0
- FWCI
- 7.70
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Synaptic Rearrangement in the Dentate Gyrus: Histochemical Evidence of Adjustments after Lesions in Immature and Adult Rats. https://app.cochat.ai/papers/10.1073/pnas.70.12.3473
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- Cotman, C. W., Matthews, D. A., Taylor, D., & Lynch, G. (1973). Synaptic Rearrangement in the Dentate Gyrus: Histochemical Evidence of Adjustments after Lesions in Immature and Adult Rats. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.70.12.3473
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