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Synthesis of Guanosine Tetra- and Pentaphosphate Requires the Presence of a Codon-Specific, Uncharged Transfer Ribonucleic Acid in the Acceptor Site of Ribosomes
Open accessAbstract
The nucleotides ppGpp and pppGpp accumulate when wild-type, but not rel - , strains of Escherichia coli are starved for required amino acids. These compounds are synthesized on ribosomes, in the presence of the product of the rel gene, from GDP and GTP; ATP is used as the phosphate donor. The signal for making these compounds is the presence of an uncharged tRNA in the ribosomal acceptor site. These compounds are not accumulated if the ribosomes are actively engaged in protein synthesis.
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Citations
Cited by
Xiao, H., Kalman, M., Ikehara, K., Zemel, S., Glaser, G., & Cashel, M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)67694-5 · Cited by 721
Atkinson, G. C., Tenson, T., & Hauryliuk, V. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023479 · Cited by 447
The stringent response and physiological roles of (pp)pGpp in bacteria.
Irving, S. E., Choudhury, N. R., & Corrigan, R. M. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-00470-y · Cited by 413
Gawronski, J. D., Wong, S. M. S., Giannoukos, G., Ward, D. V., & Akerley, B. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906627106 · Cited by 371
Control of rRNA transcription in Escherichia coli
Condon, C., Squires, C., & Squires, C. L. (1995) · Microbiological Reviews · doi:10.1128/mr.59.4.623-645.1995 · Cited by 349
Metadata
- Authors
- Haseltine, W. A., & Block, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1973-05
- Volume
- 70
- Issue
- 5
- Pages
- 1564-1568
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2006257982
- Cited by
- 473
- References
- 0
- FWCI
- 10.37
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Synthesis of Guanosine Tetra- and Pentaphosphate Requires the Presence of a Codon-Specific, Uncharged Transfer Ribonucleic Acid in the Acceptor Site of Ribosomes. https://app.cochat.ai/papers/10.1073/pnas.70.5.1564
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- Haseltine, W. A., & Block, R. (1973). Synthesis of Guanosine Tetra- and Pentaphosphate Requires the Presence of a Codon-Specific, Uncharged Transfer Ribonucleic Acid in the Acceptor Site of Ribosomes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.70.5.1564
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
