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Growth Inhibition and Morphological Changes Caused by Lipophilic Acids in Mammalian Cells
Open accessAbstract
Human (HeLa, Chang liver, L-132, and Intestine 407) and other mammalian (XC, SV3T3, and chick-embryo) cells in tissue culture are at least as sensitive to inhibition by lipophilic acids and nitrite as bacteria. Some of these compounds are the most frequently used antimicrobial food additives. Short-chain fatty acids (up to hexanoate) and parabens induce, at partially inhibitory concentrations, a jagged cell shape in continuous epithelial-like cell lines, such as HeLa, Chang liver, L-132, and Intestine 407. This morphological effect is not mediated or enhanced by butyryl cyclic AMP, which specifically affects fibroblasts.
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Cited by
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Candido, E. (1978) · Cell · doi:10.1016/0092-8674(78)90305-7 · Cited by 1,036
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Glozak, M. A., & Seto, E. (2007) · Oncogene · doi:10.1038/sj.onc.1210610 · Cited by 1,031
The neuropharmacology of butyrate: the bread and butter of the microbiota-gut-brain axis
Stilling, R. M., van de Wouw, M., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.06.011 · Cited by 891
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Kruh, J. (1981) · Molecular and Cellular Biochemistry · doi:10.1007/bf00222695 · Cited by 802
Metadata
- Authors
- Ginsburg, E., Salomon, D., Sreevalsan, T., & Freese, E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1973-08
- Volume
- 70
- Issue
- 8
- Pages
- 2457-2461
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2067839546
- Cited by
- 176
- References
- 0
- FWCI
- 9.77
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Growth Inhibition and Morphological Changes Caused by Lipophilic Acids in Mammalian Cells. https://app.cochat.ai/papers/10.1073/pnas.70.8.2457
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- Ginsburg, E., Salomon, D., Sreevalsan, T., & Freese, E. (1973). Growth Inhibition and Morphological Changes Caused by Lipophilic Acids in Mammalian Cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.70.8.2457
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